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Glyceryl trinitrate 0.2
Glyceryl trinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow.
Glyceryl trinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow. Used for Acute angina pectoris, Chronic angina prophylaxis, Heart failure (acute decompensated).
At a glance
| Generic name | Glyceryl trinitrate 0.2 |
|---|---|
| Also known as | Nitroglycerin, Perlinganit |
| Sponsor | Recep Tayyip Erdogan University |
| Drug class | Nitrate vasodilator |
| Target | Soluble guanylate cyclase (via nitric oxide) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Glyceryl trinitrate (GTN) is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle cells, increasing cGMP levels and causing vasodilation. This reduces preload and afterload on the heart, improving coronary blood flow and reducing myocardial oxygen demand. It is commonly used for acute angina relief and chronic angina prevention.
Approved indications
- Acute angina pectoris
- Chronic angina prophylaxis
- Heart failure (acute decompensated)
Common side effects
- Headache
- Dizziness
- Hypotension
- Tachycardia
- Flushing
Key clinical trials
- Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL) (NA)
- "Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy") (NA)
- Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial (PHASE4)
- Flushing Reduction Associated With Nitrates (PHASE2)
- The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting (PHASE4)
- Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure (NA)
- Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI (NA)
- Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |