{"id":"glyceryl-trinitrate-0-2","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Headache"},{"rate":"5-10","effect":"Dizziness"},{"rate":"5-15","effect":"Hypotension"},{"rate":"5-10","effect":"Tachycardia"},{"rate":"5-10","effect":"Flushing"}]},"_chembl":{"chemblId":"CHEMBL730","moleculeType":"Small molecule","molecularWeight":"227.08"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glyceryl trinitrate (GTN) is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle cells, increasing cGMP levels and causing vasodilation. This reduces preload and afterload on the heart, improving coronary blood flow and reducing myocardial oxygen demand. It is commonly used for acute angina relief and chronic angina prevention.","oneSentence":"Glyceryl trinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:47:11.001Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute angina pectoris"},{"name":"Chronic angina prophylaxis"},{"name":"Heart failure (acute decompensated)"}]},"trialDetails":[{"nctId":"NCT06273293","phase":"NA","title":"Postprocedural Contrast Mediated FFR Plus Intracoronary Infusion of Nitroglycerin in Multivessel Patients (PROMETEUS TRIAL)","status":"RECRUITING","sponsor":"Fundación EPIC","startDate":"2024-05-31","conditions":"Coronary Disease","enrollment":150},{"nctId":"NCT07159334","phase":"NA","title":"\"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy\")","status":"RECRUITING","sponsor":"King Edward Medical University","startDate":"2025-08-02","conditions":"Hemorrhoid, Postoperative Pain","enrollment":64},{"nctId":"NCT06859554","phase":"PHASE4","title":"Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial","status":"COMPLETED","sponsor":"Hafiz Muhammad Hamza","startDate":"2025-03-17","conditions":"Acute Anal Fissure, Anal Pain, Anorectal Disorders","enrollment":110},{"nctId":"NCT02714205","phase":"PHASE2","title":"Flushing Reduction Associated With Nitrates","status":"COMPLETED","sponsor":"Alison Huang, MD","startDate":"2017-04-24","conditions":"Menopausal Hot Flashes","enrollment":141},{"nctId":"NCT03251599","phase":"PHASE4","title":"The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting","status":"COMPLETED","sponsor":"Recep Tayyip Erdogan University","startDate":"2017-08-16","conditions":"Coronary Artery Bypass, Cardiopulmonary Bypass","enrollment":78},{"nctId":"NCT05590520","phase":"NA","title":"Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure","status":"UNKNOWN","sponsor":"Pak Emirates Military Hospital","startDate":"2022-11-01","conditions":"Fissure in Ano","enrollment":90},{"nctId":"NCT05682716","phase":"NA","title":"Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI","status":"COMPLETED","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2022-07-15","conditions":"Acute Kidney Injury","enrollment":137},{"nctId":"NCT04953156","phase":"","title":"Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension","status":"COMPLETED","sponsor":"National Cancer Institute, Egypt","startDate":"2021-07-03","conditions":"Hypertension","enrollment":77},{"nctId":"NCT03585452","phase":"NA","title":"Effects of Dexmedetomidine on Cognitive Outcome and Brain Injury Markers","status":"COMPLETED","sponsor":"Michał Kowalczyk","startDate":"2018-08-01","conditions":"Cognitive Dysfunction","enrollment":23},{"nctId":"NCT03813992","phase":"PHASE3","title":"Clinical Trial Using Topically Applied Glyceryl Trinitrate (GTN) for the Treatment of Erectile Dysfunction","status":"COMPLETED","sponsor":"Futura Medical Developments Ltd.","startDate":"2018-11-01","conditions":"Erectile Dysfunction","enrollment":1005},{"nctId":"NCT05241054","phase":"NA","title":"Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2022-03","conditions":"Patient With Nasolacrimal Duct Obstruction, External Dacryocystorhinostomy Operation","enrollment":64},{"nctId":"NCT01270139","phase":"NA","title":"Plasmonic Nanophotothermal Therapy of Atherosclerosis","status":"COMPLETED","sponsor":"Ural State Medical University","startDate":"2007-04-01","conditions":"Stable Angina, Heart Failure, Atherosclerosis","enrollment":180},{"nctId":"NCT01407107","phase":"PHASE1","title":"Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2011-01","conditions":"Rectal Cancer","enrollment":13},{"nctId":"NCT02495467","phase":"PHASE2","title":"Clinical Trial of Topically-applied Glyceryl Trinitrate (GTN) for the Treatment of Erectile Dysfunction (ED)","status":"COMPLETED","sponsor":"Futura Medical Developments Ltd.","startDate":"2015-05-15","conditions":"Erectile Dysfunction","enrollment":232},{"nctId":"NCT03528772","phase":"NA","title":"Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2018-05-10","conditions":"Anal Fissure","enrollment":62},{"nctId":"NCT04008732","phase":"PHASE1","title":"Evaluating MED2005 & Nitrostat Bioavailability","status":"COMPLETED","sponsor":"Futura Medical Developments Ltd.","startDate":"2017-11-15","conditions":"Erectile Dysfunction","enrollment":40},{"nctId":"NCT03569046","phase":"NA","title":"General Anesthesia With or Without Local Ear Block in Middle Ear Surgeries","status":"COMPLETED","sponsor":"Abd-Elazeem Abd-Elhameed Elbakry","startDate":"2018-07-06","conditions":"Tympanum; Perforation","enrollment":80},{"nctId":"NCT00223717","phase":"PHASE1","title":"Treatment of Supine Hypertension in Autonomic Failure","status":"COMPLETED","sponsor":"Vanderbilt University","startDate":"2001-01","conditions":"Hypertension","enrollment":152},{"nctId":"NCT01785589","phase":"PHASE4","title":"Validation of Myocardial Perfusion Imaging","status":"COMPLETED","sponsor":"University Hospital, Grenoble","startDate":"2012-05","conditions":"Coronary Artery Disease","enrollment":220},{"nctId":"NCT00998439","phase":"PHASE2","title":"Treatment of Drug-eluting Stent (DES) In-Stent Restenosis With SeQuent® Please Paclitaxel Eluting Percutaneous Transluminal Coronary Angioplasty (PTCA) Catheter","status":"UNKNOWN","sponsor":"Klinikum Coburg","startDate":"2009-10","conditions":"In-Stent Restenosis","enrollment":120},{"nctId":"NCT01162824","phase":"NA","title":"Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries","status":"UNKNOWN","sponsor":"St George's Healthcare NHS Trust","startDate":"2011-01","conditions":"Endothelial Dysfunction, Atherosclerosis, Inflammation","enrollment":50},{"nctId":"NCT00927849","phase":"NA","title":"Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2002-09","conditions":"Hypertensive Anal Canal","enrollment":63}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"NASAL DRYNESS"},{"count":1,"reaction":"POLLAKIURIA"},{"count":1,"reaction":"RHINORRHOEA"}],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Nitroglycerin, Perlinganit"],"phase":"marketed","status":"active","brandName":"Glyceryl trinitrate 0.2","genericName":"Glyceryl trinitrate 0.2","companyName":"Recep Tayyip Erdogan University","companyId":"recep-tayyip-erdogan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glyceryl trinitrate is a nitrate vasodilator that releases nitric oxide to relax vascular smooth muscle and improve blood flow. Used for Acute angina pectoris, Chronic angina prophylaxis, Heart failure (acute decompensated).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}