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Glycerin ear drops
Glycerin ear drops work by drawing fluid out of the middle ear through osmotic action, reducing pressure and relieving ear discomfort.
Glycerin ear drops work by drawing fluid out of the middle ear through osmotic action, reducing pressure and relieving ear discomfort. Used for Acute otitis media with effusion, Serous otitis media (otitis media with effusion).
At a glance
| Generic name | Glycerin ear drops |
|---|---|
| Also known as | placebo |
| Sponsor | Arbor Pharmaceuticals, Inc. |
| Drug class | Osmotic agent |
| Modality | Small molecule |
| Therapeutic area | Otolaryngology |
| Phase | Phase 3 |
Mechanism of action
Glycerin is a hygroscopic agent that creates an osmotic gradient when applied topically to the ear canal. This gradient pulls fluid from the middle ear space across the tympanic membrane, thereby reducing middle ear pressure and associated symptoms such as pain, fullness, and conductive hearing loss. The mechanism is particularly useful in acute otitis media with effusion or serous otitis media.
Approved indications
- Acute otitis media with effusion
- Serous otitis media (otitis media with effusion)
Common side effects
- Ear irritation or discomfort
- Allergic contact dermatitis
- Temporary hearing changes
Key clinical trials
- Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media (PHASE2)
- Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene (NA)
- Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care (PHASE2, PHASE3)
- Development and Validation of an Investigator Global Assessment Score for Keratosis Pilaris
- Topical Management of Xerostomia With Dry Mouth Products (NA)
- Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007) (PHASE3)
- Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (PHASE3)
- Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Glycerin ear drops CI brief — competitive landscape report
- Glycerin ear drops updates RSS · CI watch RSS
- Arbor Pharmaceuticals, Inc. portfolio CI