{"id":"glycerin-ear-drops","safety":{"commonSideEffects":[{"rate":null,"effect":"Ear irritation or discomfort"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Temporary hearing changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glycerin is a hygroscopic agent that creates an osmotic gradient when applied topically to the ear canal. This gradient pulls fluid from the middle ear space across the tympanic membrane, thereby reducing middle ear pressure and associated symptoms such as pain, fullness, and conductive hearing loss. The mechanism is particularly useful in acute otitis media with effusion or serous otitis media.","oneSentence":"Glycerin ear drops work by drawing fluid out of the middle ear through osmotic action, reducing pressure and relieving ear discomfort.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:47:32.139Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute otitis media with effusion"},{"name":"Serous otitis media (otitis media with effusion)"}]},"trialDetails":[{"nctId":"NCT02037893","phase":"PHASE2","title":"Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media","status":"COMPLETED","sponsor":"Currax Pharmaceuticals","startDate":"2013-11","conditions":"Acute Otitis Media","enrollment":112},{"nctId":"NCT06370260","phase":"NA","title":"Assessing the Efficacy of a Hydrogen Peroxide Gel for Oral Wound Healing and Oral Hygiene","status":"COMPLETED","sponsor":"National and Kapodistrian University of Athens","startDate":"2023-05-02","conditions":"Wound Heal, Postoperative Pain, Biopsy Wound","enrollment":54},{"nctId":"NCT05983302","phase":"PHASE2, PHASE3","title":"Elimination of Odor and Treatment of Malodorous Recalcitrant Wounds by Using Supraz and PRP-FG Versus Standard of Care","status":"RECRUITING","sponsor":"Mashhad University of Medical Sciences","startDate":"2023-08-20","conditions":"Wounds and Injuries","enrollment":40},{"nctId":"NCT05535517","phase":"","title":"Development and Validation of an Investigator Global Assessment Score for Keratosis Pilaris","status":"UNKNOWN","sponsor":"Premier Specialists, Australia","startDate":"2022-08-13","conditions":"Keratosis Pilaris","enrollment":15},{"nctId":"NCT03611283","phase":"NA","title":"Topical Management of Xerostomia With Dry Mouth Products","status":"COMPLETED","sponsor":"Rosa María López-Pintor Muñoz","startDate":"2016-10-03","conditions":"Xerostomia, Sjogren's Syndrome","enrollment":28},{"nctId":"NCT02074007","phase":"PHASE3","title":"Study to Compare Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media (AR01007)","status":"TERMINATED","sponsor":"Arbor Pharmaceuticals, Inc.","startDate":"2013-12","conditions":"Acute Otitis Media","enrollment":178},{"nctId":"NCT02044341","phase":"PHASE3","title":"Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media","status":"COMPLETED","sponsor":"Arbor Pharmaceuticals, Inc.","startDate":"2013-12","conditions":"Acute Otitis Media","enrollment":304},{"nctId":"NCT01584271","phase":"PHASE2","title":"Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)","status":"UNKNOWN","sponsor":"Assuta Hospital Systems","startDate":"2011-07","conditions":"Acute Otitis Externa","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":15,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["placebo"],"phase":"phase_3","status":"active","brandName":"Glycerin ear drops","genericName":"Glycerin ear drops","companyName":"Arbor Pharmaceuticals, Inc.","companyId":"arbor-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glycerin ear drops are a small molecule modality used to treat various conditions, including Acute Otitis Media, as per ClinicalTrials.gov. They are also known by synonyms such as E-422, E422, FEMA NO. 2525, GLICEROL, GLYCERIN, and GLYCERIN.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}