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Glass Ionomer Sealant
Glass ionomer sealant releases fluoride ions to remineralize tooth structure and prevent dental caries by creating a protective barrier on tooth surfaces.
Glass ionomer sealant releases fluoride ions to remineralize tooth structure and prevent dental caries by creating a protective barrier on tooth surfaces. Used for Dental caries prevention and pit-and-fissure sealant application, Fluoride release for enamel remineralization.
At a glance
| Generic name | Glass Ionomer Sealant |
|---|---|
| Also known as | ClinproTM XT Varnish, Resin-modified Glass Ionomer Sealant |
| Sponsor | University of Sao Paulo |
| Modality | Small molecule |
| Therapeutic area | Dentistry |
| Phase | Phase 3 |
Mechanism of action
Glass ionomer materials are acid-base cements that chemically bond to tooth structure and release fluoride over time, which strengthens enamel and inhibits bacterial acid production. The material forms a physical seal that prevents bacterial colonization and acid diffusion into the tooth, reducing cavity formation. This dual mechanism of chemical remineralization and physical barrier protection makes it effective for caries prevention.
Approved indications
- Dental caries prevention and pit-and-fissure sealant application
- Fluoride release for enamel remineralization
Common side effects
- Tooth sensitivity
- Mild gingival irritation
- Material wear or loss
Key clinical trials
- Building Adaptive School-based Interventions for Caries (PHASE3)
- Glass Ionomer-Based Fissure Sealants in Children (NA)
- Minimally Invasive Protocols for the Treatment and Control of Caries Lesions in Children and Adolescents (NA)
- Clinical Performance of Flowable Giomer Versus Nanofilled Composite in Conservative Occlusal Cavities (NA)
- Comparison of the Efficacy of Three Preventive Methods to Reduce the Incidence of Coronal Caries in Schoolchildren (NA)
- One-year Survival of Fissure Sealants in Immature Permanent Molars (NA)
- Comparative Evaluation of Glass Ionomer and Resin-Based Fissure Sealants on Newly Erupted Permanent First Molars: A 24-Month Randomized Clinical Trial (NA)
- Comparative Effectiveness of Treatments to Prevent Dental Caries (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Glass Ionomer Sealant CI brief — competitive landscape report
- Glass Ionomer Sealant updates RSS · CI watch RSS
- University of Sao Paulo portfolio CI