{"id":"glass-ionomer-sealant","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth sensitivity"},{"rate":null,"effect":"Mild gingival irritation"},{"rate":null,"effect":"Material wear or loss"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glass ionomer materials are acid-base cements that chemically bond to tooth structure and release fluoride over time, which strengthens enamel and inhibits bacterial acid production. The material forms a physical seal that prevents bacterial colonization and acid diffusion into the tooth, reducing cavity formation. This dual mechanism of chemical remineralization and physical barrier protection makes it effective for caries prevention.","oneSentence":"Glass ionomer sealant releases fluoride ions to remineralize tooth structure and prevent dental caries by creating a protective barrier on tooth surfaces.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:13:58.587Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dental caries prevention and pit-and-fissure sealant application"},{"name":"Fluoride release for enamel remineralization"}]},"trialDetails":[{"nctId":"NCT07265830","phase":"PHASE3","title":"Building Adaptive School-based Interventions for Caries","status":"NOT_YET_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2026-09","conditions":"Dental Caries","enrollment":1200},{"nctId":"NCT07388472","phase":"NA","title":"Glass Ionomer-Based Fissure Sealants in Children","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2016-11","conditions":"Fissure Sealant","enrollment":200},{"nctId":"NCT06999005","phase":"NA","title":"Minimally Invasive Protocols for the Treatment and Control of Caries Lesions in Children and Adolescents","status":"NOT_YET_RECRUITING","sponsor":"University of Nove de Julho","startDate":"2026-02","conditions":"Dental Caries","enrollment":2500},{"nctId":"NCT06097143","phase":"NA","title":"Clinical Performance of Flowable Giomer Versus Nanofilled Composite in Conservative Occlusal Cavities","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-12-15","conditions":"Occlusal Caries","enrollment":42},{"nctId":"NCT07131358","phase":"NA","title":"Comparison of the Efficacy of Three Preventive Methods to Reduce the Incidence of Coronal Caries in Schoolchildren","status":"RECRUITING","sponsor":"Universidad Nacional Autonoma de Mexico","startDate":"2025-09-01","conditions":"Caries Prevention","enrollment":204},{"nctId":"NCT07143253","phase":"NA","title":"One-year Survival of Fissure Sealants in Immature Permanent Molars","status":"NOT_YET_RECRUITING","sponsor":"Handan Vural","startDate":"2025-09","conditions":"Evaluation of the Survival of Different Fissure Sealants in Partially Erupted Immature Molar Teeth at Various Eruption Stages","enrollment":40},{"nctId":"NCT07115290","phase":"NA","title":"Comparative Evaluation of Glass Ionomer and Resin-Based Fissure Sealants on Newly Erupted Permanent First Molars: A 24-Month Randomized Clinical Trial","status":"COMPLETED","sponsor":"Gulcin Bulut","startDate":"2023-04-10","conditions":"Dental Caries, Fissure Sealants, Permanent Molars","enrollment":35},{"nctId":"NCT03448107","phase":"NA","title":"Comparative Effectiveness of Treatments to Prevent Dental Caries","status":"COMPLETED","sponsor":"NYU College of Dentistry","startDate":"2017-09-20","conditions":"Dental Caries","enrollment":3345},{"nctId":"NCT03442309","phase":"NA","title":"Comparative Effectiveness of School-based Caries Prevention","status":"COMPLETED","sponsor":"NYU College of Dentistry","startDate":"2019-02-01","conditions":"Dental Caries, Quality of Life","enrollment":7418},{"nctId":"NCT06801561","phase":"NA","title":"EVALUATION of PREVENTIVE EFFECT of SEALANTS and LASER THERAPY on DENTAL CARIES and POSTERUPTIVE BREAKDOWN on MOLARS AFFECTED with MOLAR INCISOR HYPOMINERALISATION (RANDOMIZED CLINICAL TRIAL)","status":"RECRUITING","sponsor":"Alexandria University","startDate":"2024-03-01","conditions":"Molar Incisor Hypomineralization","enrollment":134},{"nctId":"NCT06641011","phase":"NA","title":"This Study Aims to Evaluate the Effect of Rinsing Off or Blot-drying Silver Fluoride on the Retention of Subsequently-applied Resin- and Glass Ionomer-based Fissure Sealants in Permanent Molars Affected by Molar-Incisor Hypomineralization.","status":"RECRUITING","sponsor":"Hacettepe University","startDate":"2023-07-31","conditions":"Molar Incisor Hypomineralisation, Children, Dental Caries","enrollment":104},{"nctId":"NCT05370417","phase":"PHASE1, PHASE2","title":"Photobiomodulation and Glass Ionomer Sealant as Complementary Treatment for Hypersensitivity in Molars With MIH","status":"COMPLETED","sponsor":"University of Nove de Julho","startDate":"2022-07-19","conditions":"Hypomineralization Molar Incisor","enrollment":50},{"nctId":"NCT05465369","phase":"PHASE3","title":"Clinical Assessment of Injectable Flowable Composite with Giomer Technology Vs High Viscosity Glass Ionomer Restorations in ART for Cancer Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-02-07","conditions":"Secondary Caries, Fracture Tooth, Discoloration, Tooth","enrollment":190},{"nctId":"NCT05806398","phase":"","title":"Use of a Glass Ionomer Sealant in Molar Incisor Hypomineralization","status":"RECRUITING","sponsor":"IRCCS Burlo Garofolo","startDate":"2022-06-01","conditions":"Molar Incisor Hypomineralization","enrollment":15},{"nctId":"NCT06154733","phase":"NA","title":"HYPERSENSITIVITY IN MOLAR INCISOR HYPOMINERALISATION USING LOW LEVEL LASER IN CHILDREN","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2024-01","conditions":"Molar Incisor Hypomineralization","enrollment":45},{"nctId":"NCT04933331","phase":"","title":"Early Caries Lesion Management Observational Study","status":"UNKNOWN","sponsor":"CareQuest Institute for Oral Health","startDate":"2020-12-07","conditions":"Initial Caries, Arrested Dental Caries, Cavitated Caries","enrollment":744},{"nctId":"NCT05988801","phase":"NA","title":"Evaluation of Glass Ionomer Sealant Versus Resin Sealant for Pits and Fissures of the First Permanent Molars","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-10","conditions":"Pits and Fissures Sealant","enrollment":88},{"nctId":"NCT05945381","phase":"NA","title":"Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation","status":"UNKNOWN","sponsor":"University Medicine Greifswald","startDate":"2023-05-01","conditions":"Hypersensitive, Molar Incisor Hypomineralization, Pit and Fissure Sealants","enrollment":18},{"nctId":"NCT05894200","phase":"","title":"Effectiveness and Retention of Pit and Fissure Sealants in Rural Setup: A School-based Clinical Trial in Nepal","status":"UNKNOWN","sponsor":"Kathmandu University School of Medical Sciences","startDate":"2023-08-10","conditions":"Dental Caries Pit and Fissure, Oral Disease","enrollment":377},{"nctId":"NCT05838469","phase":"NA","title":"Clinical Evaluation of High Viscosity Glass Ionomer Strip Crowns in Primary Maxillary Incisors","status":"UNKNOWN","sponsor":"Hacettepe University","startDate":"2022-08-02","conditions":"Early Childhood Caries","enrollment":100},{"nctId":"NCT05550116","phase":"NA","title":"Clinical Evaluation of White Spot Lesions Treated by S-PRG and ICON","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2021-08-11","conditions":"White Spot Lesion","enrollment":20},{"nctId":"NCT05475145","phase":"NA","title":"Sealing of Occlusal Dentin Caries in Primary Molars.","status":"COMPLETED","sponsor":"Mats Bågesund","startDate":"2015-02-02","conditions":"Caries; Dentin, Fissure, Dental, Dental Caries in Children","enrollment":70},{"nctId":"NCT05127343","phase":"NA","title":"Comparison Between Resin Based and Glass Ionomer Based Hydrophilic Fissure Sealants","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-02","conditions":"Caries","enrollment":48},{"nctId":"NCT04854720","phase":"NA","title":"Clinical Efficacy of Different Fissure Sealant Materials in the Newly Erupted Non-Carious First Permanent Molars","status":"COMPLETED","sponsor":"Izmir Katip Celebi University","startDate":"2019-03-10","conditions":"Fissure Sealant","enrollment":182},{"nctId":"NCT04701294","phase":"NA","title":"Retention of Flowable Resin With Sprg and of a Flowable Resin in First Permanent Molars","status":"UNKNOWN","sponsor":"Catherine Christie Ruiz Yasuda","startDate":"2021-03","conditions":"Pit and Fissure Sealant","enrollment":60},{"nctId":"NCT04591444","phase":"PHASE3","title":"Fluoride Varnish X Glass Ionomer Sealant on Cervical Dentin Hypersensitivity","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2017-01","conditions":"Dentin Hypersensitivity, Dentin Sensitivity","enrollment":121},{"nctId":"NCT03870958","phase":"NA","title":"Glass Ionomer Cement Sealant in the Prevention of Post-eruptive Fractures in Molars Affected by MIH","status":"UNKNOWN","sponsor":"Isabel Cristina Olegário da Costa","startDate":"2018-11-20","conditions":"Molar Incisor Hypomineralization","enrollment":195},{"nctId":"NCT01129440","phase":"PHASE2","title":"Glass Ionomer Sealant and Fluoride Varnish Study to Prevent Early Childhood Caries","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2011-06","conditions":"Dental Caries","enrollment":597},{"nctId":"NCT04272866","phase":"NA","title":"Comparing Bond Strength,Microleakage and Clinical Performance of Three Pit and Fissure Sealants","status":"UNKNOWN","sponsor":"Sarah Emad Ali El-Din","startDate":"2019-07-03","conditions":"Caries Prevention","enrollment":100},{"nctId":"NCT04163354","phase":"NA","title":"Glass Ionomer Sealant Versus Fluoride Varnish on Occlusal Caries Prevention","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2018-04-11","conditions":"Pit and Fissure Caries, Glass Ionomer Cements, Tooth, Deciduous","enrollment":348},{"nctId":"NCT03034837","phase":"PHASE4","title":"Effectiveness and Economic Evaluation of Glass Ionomer Material Using as Dental Sealant","status":"COMPLETED","sponsor":"Zhengzhou University","startDate":"2016-01","conditions":"Glass Ionomer Cement, Cost-effectiveness, Pit and Fissure Caries (Disorder)","enrollment":329},{"nctId":"NCT03989687","phase":"NA","title":"Clinical Retention of Glass Ionomer Sealants Placed With and Without Rubber Dam: a Comparative Analysis","status":"UNKNOWN","sponsor":"Louisiana State University Health Sciences Center in New Orleans","startDate":"2019-07-01","conditions":"Dental Caries in Children","enrollment":18},{"nctId":"NCT03667768","phase":"NA","title":"Atraumatic Restorative Treatment Sealants in First Permanent Molars","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2010-03","conditions":"Caries, Dental","enrollment":437},{"nctId":"NCT03005405","phase":"NA","title":"Cost-efficacy of Sealing Moderate Caries Lesions in Occlusal Surfaces of Primary Molars","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2015-02","conditions":"Dental Caries","enrollment":96},{"nctId":"NCT02849925","phase":"NA","title":"Sealing Microcavitated Carious Lesions","status":"COMPLETED","sponsor":"University of Talca","startDate":"2015-03","conditions":"Dental Caries","enrollment":37},{"nctId":"NCT03235960","phase":"","title":"Efficacy of Glass-ionomer Fissure Sealants","status":"UNKNOWN","sponsor":"Association of Paediatric and Preventive Dentists of Serbia","startDate":"2004-01-01","conditions":"Fissure Sealant, Glass-ionomer Cement, Permanent Molar","enrollment":500},{"nctId":"NCT03077035","phase":"NA","title":"Using ICDAS II and KaVo DIAGNOdent Pen Detecting Tooth Pit and Fissure Level Incipent Caries Progression","status":"UNKNOWN","sponsor":"Sheng-Chao Wang","startDate":"2015-10-01","conditions":"Dental Caries on Pit and Fissure Surface","enrollment":300},{"nctId":"NCT02931734","phase":"NA","title":"Assessment of Different Protocols for Cervical Dentin Hypersensitivity Treatment","status":"COMPLETED","sponsor":"Federal University of Uberlandia","startDate":"2014-10","conditions":"Hypersensitivity Dentin, Dentin Sensitivity, Dentin Hypersensitivity","enrollment":140},{"nctId":"NCT02659917","phase":"PHASE1","title":"Performance of Glass-ionomer Cements: 2-year Follow-up","status":"COMPLETED","sponsor":"Fernanda Miori Pascon","startDate":"2008-08","conditions":"Dental Caries","enrollment":147},{"nctId":"NCT02063815","phase":"NA","title":"A Trial of Caries Prevention Effect of Fissure Sealants","status":"COMPLETED","sponsor":"Marmara University","startDate":"2009-06","conditions":"Caries Prevention, Fissure Sealant, Fluoride Concentration","enrollment":40},{"nctId":"NCT01829334","phase":"PHASE2","title":"Cost-effectiveness of Four Methods in Preventing Fissure Caries in Permanent Teeth","status":"COMPLETED","sponsor":"The University of Hong Kong","startDate":"2006-06","conditions":"Dental Caries","enrollment":329},{"nctId":"NCT01588210","phase":"NA","title":"Fluoride Concentration in Inter-proximal Fluid From Dental Sealants","status":"COMPLETED","sponsor":"Università degli Studi di Sassari","startDate":"2008-01","conditions":"Caries","enrollment":2776}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":77,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["ClinproTM XT Varnish","Resin-modified Glass Ionomer Sealant"],"phase":"phase_3","status":"active","brandName":"Glass Ionomer Sealant","genericName":"Glass Ionomer Sealant","companyName":"University of Sao Paulo","companyId":"university-of-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Glass ionomer sealant releases fluoride ions to remineralize tooth structure and prevent dental caries by creating a protective barrier on tooth surfaces. Used for Dental caries prevention and pit-and-fissure sealant application, Fluoride release for enamel remineralization.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}