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Ginger-ibuprofen
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while ginger provides additional anti-inflammatory and analgesic effects through multiple pathways.
Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while ginger provides additional anti-inflammatory and analgesic effects through multiple pathways. Used for Pain and inflammation (general indication for marketed NSAID-ginger combination).
At a glance
| Generic name | Ginger-ibuprofen |
|---|---|
| Sponsor | Ferrosan AS |
| Drug class | NSAID with herbal adjunct |
| Target | COX-1, COX-2 (ibuprofen component); multiple inflammatory pathways (ginger component) |
| Modality | Small molecule |
| Therapeutic area | Pain management, Inflammation |
| Phase | FDA-approved |
Mechanism of action
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, thereby reducing prostaglandin production and decreasing inflammation, pain, and fever. Ginger contains gingerols and shogaols that inhibit inflammatory mediators and may enhance the anti-inflammatory effect. This combination product leverages both mechanisms to provide analgesic and anti-inflammatory benefits.
Approved indications
- Pain and inflammation (general indication for marketed NSAID-ginger combination)
Common side effects
- Gastrointestinal upset
- Dyspepsia
- Nausea
- Headache
Key clinical trials
- Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model (PHASE2)
- Glucosamine Sulphate, Ginger, Ginger-Avocado-Soya and Ginger-Ibuprofen for Chronic Back Pain (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |