{"id":"ginger-ibuprofen","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dyspepsia"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2108465","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that blocks COX-1 and COX-2 enzymes, thereby reducing prostaglandin production and decreasing inflammation, pain, and fever. Ginger contains gingerols and shogaols that inhibit inflammatory mediators and may enhance the anti-inflammatory effect. This combination product leverages both mechanisms to provide analgesic and anti-inflammatory benefits.","oneSentence":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while ginger provides additional anti-inflammatory and analgesic effects through multiple pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:31:16.949Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pain and inflammation (general indication for marketed NSAID-ginger combination)"}]},"trialDetails":[{"nctId":"NCT01429935","phase":"PHASE2","title":"Anti Inflammatory and Analgesic Effect of Ginger Powder in Dental Pain Model","status":"UNKNOWN","sponsor":"Qazvin University Of Medical Sciences","startDate":"2010-06","conditions":"Impacted Third Molar Tooth","enrollment":60},{"nctId":"NCT00317655","phase":"PHASE4","title":"Glucosamine Sulphate, Ginger, Ginger-Avocado-Soya and Ginger-Ibuprofen for Chronic Back Pain","status":"COMPLETED","sponsor":"Ferrosan AS","startDate":"2006-04","conditions":"Back Pain","enrollment":175}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ginger-ibuprofen","genericName":"Ginger-ibuprofen","companyName":"Ferrosan AS","companyId":"ferrosan-as","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ibuprofen inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis and inflammation, while ginger provides additional anti-inflammatory and analgesic effects through multiple pathways. Used for Pain and inflammation (general indication for marketed NSAID-ginger combination).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}