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gadoxetic acid enhanced liver MRI
gadoxetic acid enhanced liver MRI is a Gadolinium-based contrast agent Small molecule drug developed by Seoul National University Hospital. It is currently FDA-approved for Liver MRI for detection and characterization of focal hepatic lesions, Evaluation of cirrhosis and hepatocellular carcinoma. Also known as: Primovist, Eovist.
Gadoxetic acid is a gadolinium-based contrast agent that accumulates in hepatocytes to enhance MRI visualization of liver tissue and detect lesions.
Gadoxetic acid is a gadolinium-based contrast agent that accumulates in hepatocytes to enhance MRI visualization of liver tissue and detect lesions. Used for Liver MRI for detection and characterization of focal hepatic lesions, Evaluation of cirrhosis and hepatocellular carcinoma.
At a glance
| Generic name | gadoxetic acid enhanced liver MRI |
|---|---|
| Also known as | Primovist, Eovist |
| Sponsor | Seoul National University Hospital |
| Drug class | Gadolinium-based contrast agent |
| Target | Organic anion transporter 1B1/1B3 (OATP1B1/1B3) |
| Modality | Small molecule |
| Therapeutic area | Diagnostic Imaging |
| Phase | FDA-approved |
Mechanism of action
Gadoxetic acid is a hepatobiliary contrast agent containing gadolinium that is taken up by hepatocytes via organic anion transporters and excreted into bile. This dual uptake mechanism allows for both vascular phase imaging (from the gadolinium contrast effect) and hepatobiliary phase imaging (from hepatocyte accumulation), improving detection and characterization of focal liver lesions on MRI.
Approved indications
- Liver MRI for detection and characterization of focal hepatic lesions
- Evaluation of cirrhosis and hepatocellular carcinoma
Common side effects
- Gadolinium deposition in tissues
- Nephrogenic systemic fibrosis (rare, in severe renal impairment)
- Injection site reactions
- Headache
- Nausea
Key clinical trials
- A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer (PHASE2)
- REGULUS: MRI-guided Adaptive SABR for Liver Cancers (PHASE2)
- Contrast-enhanced MRI in Detecting Benign and Malignant Liver Lesions (NA)
- Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer (NA)
- Pharmacologic Approaches to Preventing Primary Sclerosing Cholangitis Recurrence After Liver Transplantation (PHASE2)
- Comparison of ultraSound, Abbreviated MRI witH and Without HBP aS mOdalities for HCC suRveillance in patienTs With High Risk (NA)
- An Observational Study to Learn More About the Impact of Gadoxetate Sodium-Enhanced Magnetic Resonance Imaging (EOB-MRI) When Used to Diagnose the Spread of Cancer From the Pancreas to the Liver in Japanese People Under Real-World Conditions
- Comparison of Gd-EOB-DTPA-enhanced MRI and Contrast-enhanced Ultrasound for Measuring Tumor Size of Solitary Hepatocellular Carcinoma ≤ 5cm:A Retrospective Study
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- gadoxetic acid enhanced liver MRI CI brief — competitive landscape report
- gadoxetic acid enhanced liver MRI updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI
Frequently asked questions about gadoxetic acid enhanced liver MRI
What is gadoxetic acid enhanced liver MRI?
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Related
- Drug class: All Gadolinium-based contrast agent drugs
- Target: All drugs targeting Organic anion transporter 1B1/1B3 (OATP1B1/1B3)
- Manufacturer: Seoul National University Hospital — full pipeline
- Therapeutic area: All drugs in Diagnostic Imaging
- Indication: Drugs for Liver MRI for detection and characterization of focal hepatic lesions
- Indication: Drugs for Evaluation of cirrhosis and hepatocellular carcinoma
- Also known as: Primovist, Eovist
- Compare: gadoxetic acid enhanced liver MRI vs similar drugs
- Pricing: gadoxetic acid enhanced liver MRI cost, discount & access