What are Gadolinium-based contrast agent drugs?

Gadolinium-based contrast agent drugs are pharmacologic agents that share a common mechanism (typically targeting Water proton relaxation (T1 and T2 relaxation times)). 9 are currently marketed, with 6 more in clinical development.

What are the marketed Gadolinium-based contrast agent drugs?

Marketed Gadolinium-based contrast agent drugs include DOTAREM, Gadopentetate-Dimeglumine 0.0125 mmol, Gadopentetate-Dimeglumine 0.05 mmol, Gadoterate (Dotarem/Clariscan), gadoxetic acid enhanced liver MRI, Gadoteric Acid Meglumine Salt.

Gadolinium-based contrast agent

9 marketed 6 in Phase 3

This page covers all Gadolinium-based contrast agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Water proton relaxation (T1 and T2 relaxation times), Water proton relaxation (T1 relaxation time), Water protons (T1 relaxation enhancement).

Targets

Water proton relaxation (T1 and T2 relaxation times) · Water proton relaxation (T1 relaxation time) · Water protons (T1 relaxation enhancement) · Water protons (via paramagnetic gadolinium ion) · Organic anion transporter 1B1/1B3 (OATP1B1/1B3) · Water proton relaxation (T1 relaxation enhancement) · Water protons (paramagnetic enhancement)

Marketed (9)

DOTAREM · Guerbet · Diagnostic Imaging
DOTAREM is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the relaxation time of water protons in tissues.
Gadopentetate-Dimeglumine 0.0125 mmol · Paracelsus Medical University · Diagnostic Imaging
Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by altering the relaxation properties of water protons.
Gadopentetate-Dimeglumine 0.05 mmol · Paracelsus Medical University · Diagnostic Imaging
Gadopentetate dimeglumine is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by shortening T1 relaxation time.
Gadoterate (Dotarem/Clariscan) · Bayer · Diagnostic Imaging
Gadoterate is a gadolinium-based contrast agent that accumulates in tissues and enhances MRI signal to improve visualization of anatomical structures and lesions.
gadoxetic acid enhanced liver MRI · Seoul National University Hospital · Diagnostic Imaging
Gadoxetic acid is a gadolinium-based contrast agent that accumulates in hepatocytes to enhance MRI visualization of liver tissue and detect lesions.
Gadoteric Acid Meglumine Salt · The Central Hospital of Lishui City · Diagnostic Imaging
Gadoteric acid meglumine salt is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
MultiHance 0.05 mmol/kg · Bracco Diagnostics, Inc · Diagnostic Imaging
MultiHance is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
Gadovist®/Gadavist® · Guerbet · Diagnostic Imaging
Gadovist is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the relaxation time of water protons in tissues.
Dotarem®-enhanced MRI · Guerbet · Diagnostic Imaging
Dotarem is a gadolinium-based contrast agent that enhances MRI signal by altering the magnetic properties of nearby water molecules in tissues.

Phase 3 pipeline (6)

Gadoquatrane (BAY1747846) · Bayer · Diagnostic Imaging
Gadoquatrane is a gadolinium-based contrast agent designed for magnetic resonance imaging (MRI) that provides enhanced visualization of blood vessels and tissues.
Magnevist (SH L 451A) · Bayer · Diagnostic Imaging
Magnevist is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
Dotarem (gadoterate meglumine) · Guerbet · Diagnostic Imaging
Gadoterate meglumine is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
Gadoteridol (ProHance) · Bayer · Diagnostic Imaging
Gadoteridol is a gadolinium-based contrast agent that enhances magnetic resonance imaging (MRI) by shortening the T1 relaxation time of water protons in tissues.
Gadodiamide Injection · GE Healthcare · Diagnostic Imaging
Gadodiamide is a gadolinium-based contrast agent that enhances magnetic resonance imaging by shortening the T1 relaxation time of water protons in tissues.
Gadobutrol Injection · Shanghai Shengdi Pharmaceutical Co., Ltd · Diagnostic Imaging
Gadobutrol is a gadolinium-based contrast agent that accumulates in tissues and enhances magnetic resonance imaging (MRI) signal by shortening T1 relaxation time.