Last reviewed 2026-04-23 · How we verify

Fospropofol disodium for injection

Fospropofol disodium is a prodrug that is converted to propofol, a GABA_A receptor agonist, leading to sedation and hypnosis.

Fospropofol disodium is a prodrug that is converted to propofol, a GABA_A receptor agonist, leading to sedation and hypnosis. Used for Sedation for diagnostic or surgical procedures.

At a glance

Mechanism of action

Fospropofol disodium is a water-soluble prodrug that is metabolized to propofol, which then acts as a potent agonist of the GABA_A receptor. This results in the enhancement of inhibitory neurotransmission in the brain, leading to sedative and hypnotic effects.

Approved indications

• Sedation for diagnostic or surgical procedures

Common side effects

• Respiratory depression
• Hypotension
• Nausea and vomiting

Key clinical trials

• Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment (NA)
• Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients (PHASE2)
• Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients (PHASE2)
• A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Elderly Patients Undergoing Elective Colonoscopy (PHASE2)
• A Study of AQUAVAN® Injection for Sedation in Elderly Patients Undergoing Flexible Bronchoscopy (PHASE3)
• A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion (PHASE1)
• A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures (PHASE3)
• Evaluate The Effectiveness Of Fospropofol (Lusedra®) For Induction Of Anesthesia (NA)

Primary sources

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