{"id":"fospropofol-disodium-for-injection","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Respiratory depression"},{"rate":"10-20%","effect":"Hypotension"},{"rate":"5-10%","effect":"Nausea and vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Fospropofol disodium is a water-soluble prodrug that is metabolized to propofol, which then acts as a potent agonist of the GABA_A receptor. This results in the enhancement of inhibitory neurotransmission in the brain, leading to sedative and hypnotic effects.","oneSentence":"Fospropofol disodium is a prodrug that is converted to propofol, a GABA_A receptor agonist, leading to sedation and hypnosis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:32:53.008Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Sedation for diagnostic or surgical procedures"}]},"trialDetails":[{"nctId":"NCT06732427","phase":"NA","title":"Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment","status":"RECRUITING","sponsor":"Affiliated Hospital of Nantong University","startDate":"2025-08-12","conditions":"Efficacy and Safety","enrollment":426},{"nctId":"NCT05491278","phase":"PHASE2","title":"Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients","status":"COMPLETED","sponsor":"Xiaobo Yang, MD","startDate":"2022-08-10","conditions":"Critical Illness","enrollment":60},{"nctId":"NCT05870514","phase":"PHASE2","title":"Efficacy and Safety of Fospropofol Disodium Versus Propofol for Deep Sedation in Critically Ill Patients","status":"UNKNOWN","sponsor":"Xiaobo Yang, MD","startDate":"2023-06-01","conditions":"Critical Illness","enrollment":60},{"nctId":"NCT00209599","phase":"PHASE2","title":"A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Elderly Patients Undergoing Elective Colonoscopy","status":"TERMINATED","sponsor":"Eisai Inc.","startDate":"2005-02","conditions":"Colonoscopy, Colon Polyps","enrollment":100},{"nctId":"NCT00209586","phase":"PHASE3","title":"A Study of AQUAVAN® Injection for Sedation in Elderly Patients Undergoing Flexible Bronchoscopy","status":"TERMINATED","sponsor":"Eisai Inc.","startDate":"2004-09","conditions":"Flexible Bronchoscopy","enrollment":55},{"nctId":"NCT01308541","phase":"PHASE1","title":"A Study to Characterize Pharmacokinetics (PK) and Pharmacodynamics (PD) of LUSEDRA® Administered as Continuous Infusion or Bolus Compared With Continuous Infusion of Propofol Injectable Emulsion","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2011-01","conditions":"Monitored Anesthesia Care","enrollment":20},{"nctId":"NCT00209560","phase":"PHASE3","title":"A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Minor Surgical Procedures","status":"TERMINATED","sponsor":"Eisai Inc.","startDate":"2004-10","conditions":"Arthroscopy, Bunionectomy, Osteotomy","enrollment":168},{"nctId":"NCT01378754","phase":"NA","title":"Evaluate The Effectiveness Of Fospropofol (Lusedra®) For Induction Of Anesthesia","status":"WITHDRAWN","sponsor":"Grace Shih, MD","startDate":"2011-06","conditions":"Interstitial Cystitis","enrollment":""},{"nctId":"NCT00327392","phase":"PHASE2, PHASE3","title":"A Safety Study of AQUAVAN® (Fospropofol Disodium) Injection for Sedation During Minor Surgical Procedures.","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2006-05","conditions":"Procedural Sedation","enrollment":123},{"nctId":"NCT00209521","phase":"PHASE2","title":"Comparison of AQUAVAN® Injection to DISOPRIVAN® Injectable Emulsion for Anesthesia During Coronary Artery Surgery","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2002-06","conditions":"Ischemic Coronary Artery Disease, Coronary Artery Bypass Surgery","enrollment":16},{"nctId":"NCT00125424","phase":"PHASE2, PHASE3","title":"Study of AQUAVAN® Injection (AQUAVAN; Fospropofol Disodium) for Sedation During Colonoscopy","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2005-07","conditions":"Colonoscopy, Colonic Polyps","enrollment":125},{"nctId":"NCT00209547","phase":"PHASE3","title":"Study to Assess Safety and Efficacy of AQUAVAN® Injection for Sedation During Cardiac Catheterization","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2004-02","conditions":"Angioplasty, Coronary Catheterization","enrollment":110},{"nctId":"NCT00261599","phase":"PHASE3","title":"An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Colonoscopy","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2006-03","conditions":"Conscious Sedation","enrollment":300},{"nctId":"NCT00209573","phase":"PHASE3","title":"A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Elective Colonoscopy","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2004-09","conditions":"Colonoscopy, Colon Polyps","enrollment":270},{"nctId":"NCT00306722","phase":"PHASE3","title":"An Effectiveness and Safety Study of AQUAVAN® Injection (Fospropofol Disodium) for Sedation During Flexible Bronchoscopy","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2006-04","conditions":"Bronchoscopy, Anesthesia","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Remifentanil","sulfentanyl"],"phase":"phase_2","status":"active","brandName":"Fospropofol disodium for injection","genericName":"Fospropofol disodium for injection","companyName":"Xiaobo Yang, MD","companyId":"xiaobo-yang-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fospropofol disodium for injection is a small molecule with an unknown mechanism of action. It is used for deep sedation in critically ill patients, as well as in various surgical procedures such as arthroscopy, bunionectomy, osteotomy, and carpal tunnel surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}