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Fluticasone furoate and fexofenadine

GlaxoSmithKline · FDA-approved active Small molecule

Fluticasone furoate and fexofenadine is a Intranasal corticosteroid and antihistamine combination Small molecule drug developed by GlaxoSmithKline. It is currently FDA-approved for Allergic rhinitis (seasonal and perennial).

This combination reduces allergic inflammation through a corticosteroid that suppresses immune response in the nasal airways and an antihistamine that blocks histamine receptors.

This combination reduces allergic inflammation through a corticosteroid that suppresses immune response in the nasal airways and an antihistamine that blocks histamine receptors. Used for Allergic rhinitis (seasonal and perennial).

At a glance

Generic nameFluticasone furoate and fexofenadine
SponsorGlaxoSmithKline
Drug classIntranasal corticosteroid and antihistamine combination
TargetGlucocorticoid receptor (fluticasone furoate); H1 histamine receptor (fexofenadine)
ModalitySmall molecule
Therapeutic areaAllergy/Immunology
PhaseFDA-approved

Mechanism of action

Fluticasone furoate is an intranasal corticosteroid that inhibits inflammatory mediator release and immune cell activation in the nasal mucosa. Fexofenadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic symptoms. Together, they provide dual anti-inflammatory and antihistamine action for allergic rhinitis.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Fluticasone furoate and fexofenadine

What is Fluticasone furoate and fexofenadine?

Fluticasone furoate and fexofenadine is a Intranasal corticosteroid and antihistamine combination drug developed by GlaxoSmithKline, indicated for Allergic rhinitis (seasonal and perennial).

How does Fluticasone furoate and fexofenadine work?

This combination reduces allergic inflammation through a corticosteroid that suppresses immune response in the nasal airways and an antihistamine that blocks histamine receptors.

What is Fluticasone furoate and fexofenadine used for?

Fluticasone furoate and fexofenadine is indicated for Allergic rhinitis (seasonal and perennial).

Who makes Fluticasone furoate and fexofenadine?

Fluticasone furoate and fexofenadine is developed and marketed by GlaxoSmithKline (see full GlaxoSmithKline pipeline at /company/gsk).

What drug class is Fluticasone furoate and fexofenadine in?

Fluticasone furoate and fexofenadine belongs to the Intranasal corticosteroid and antihistamine combination class. See all Intranasal corticosteroid and antihistamine combination drugs at /class/intranasal-corticosteroid-and-antihistamine-combination.

What development phase is Fluticasone furoate and fexofenadine in?

Fluticasone furoate and fexofenadine is FDA-approved (marketed).

What are the side effects of Fluticasone furoate and fexofenadine?

Common side effects of Fluticasone furoate and fexofenadine include Headache, Epistaxis, Nasal irritation, Pharyngitis.

What does Fluticasone furoate and fexofenadine target?

Fluticasone furoate and fexofenadine targets Glucocorticoid receptor (fluticasone furoate); H1 histamine receptor (fexofenadine) and is a Intranasal corticosteroid and antihistamine combination.

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