{"id":"fluticasone-furoate-and-fexofenadine","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Epistaxis"},{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Pharyngitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluticasone furoate is an intranasal corticosteroid that inhibits inflammatory mediator release and immune cell activation in the nasal mucosa. Fexofenadine is a selective H1-receptor antagonist that blocks histamine-mediated allergic symptoms. Together, they provide dual anti-inflammatory and antihistamine action for allergic rhinitis.","oneSentence":"This combination reduces allergic inflammation through a corticosteroid that suppresses immune response in the nasal airways and an antihistamine that blocks histamine receptors.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:46:45.738Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis (seasonal and perennial)"}]},"trialDetails":[{"nctId":"NCT00435461","phase":"PHASE4","title":"Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-12-20","conditions":"Rhinitis, Allergic, Seasonal","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fluticasone furoate and fexofenadine","genericName":"Fluticasone furoate and fexofenadine","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination reduces allergic inflammation through a corticosteroid that suppresses immune response in the nasal airways and an antihistamine that blocks histamine receptors. Used for Allergic rhinitis (seasonal and perennial).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}