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Fluid resuscitation with Ringer Lactate
Ringer Lactate is a crystalloid fluid that restores intravascular volume and electrolyte balance in hypovolemic or dehydrated patients.
Ringer Lactate is a crystalloid fluid that restores intravascular volume and electrolyte balance in hypovolemic or dehydrated patients. Used for Hypovolemic shock (hemorrhagic and non-hemorrhagic), Acute dehydration, Perioperative fluid replacement.
At a glance
| Generic name | Fluid resuscitation with Ringer Lactate |
|---|---|
| Sponsor | Centre Hospitalier Universitaire de Nice |
| Drug class | Crystalloid fluid / Electrolyte solution |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Emergency Medicine / Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Ringer Lactate is a balanced electrolyte solution containing sodium, potassium, calcium, chloride, and lactate in physiologic concentrations. It rapidly expands the extracellular fluid compartment to restore perfusion and oxygen delivery to tissues. The lactate component is metabolized by the liver to bicarbonate, providing mild alkalinizing effects and reducing hyperchloremic acidosis compared to normal saline.
Approved indications
- Hypovolemic shock (hemorrhagic and non-hemorrhagic)
- Acute dehydration
- Perioperative fluid replacement
- Burn management
- Septic shock fluid resuscitation
Common side effects
- Hyperkalemia
- Fluid overload / pulmonary edema
- Hyponatremia
- Hypothermia (if infused cold)
- Phlebitis at infusion site
Key clinical trials
- Precision Resuscitation With Crystalloids in Sepsis (NA)
- Volume Kinetics of Fluid Resuscitation in Early Sepsis
- Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PHASE3)
- Strong Albumin Solutions in Patients With Septic Shock (PHASE2, PHASE3)
- Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage (NA)
- Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis (PHASE4)
- Acute Normovolemic Hemodilution in High Risk Cardiac Surgery Patients. (NA)
- Randomized Control Study in REsuscitation of SEpsis Trial (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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