Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage - a Multi-center Randomized Double-blind Clinical Trial (CRYSTALLBrain)

NCT04043598 NA RECRUITING

Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.

Details

Lead sponsor	Insel Gruppe AG, University Hospital Bern
Phase	NA
Status	RECRUITING
Enrolment	320
Start date	2022-05-24
Completion	2027-12

Conditions

• Subarachnoid Hemorrhage
• Critical Illness
• Infusion Fluid
• Sodium Disorder

Interventions

• 0.9% Sodium-chloride
• Ringer's Lactate

Primary outcomes

• Number of patients with clinically relevant vasospasms — From ICU admission until discharge (usually within the first 21 days)
  Defined as new neurologic deficit requiring immediate intervention

Countries

Switzerland