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Fluconazole and Secnidazole

Fluconazole and secnidazole is a combination antifungal and antiprotozoal agent that inhibits fungal ergosterol synthesis and disrupts protozoal DNA, respectively.

Fluconazole and secnidazole is a combination antifungal and antiprotozoal agent that inhibits fungal ergosterol synthesis and disrupts protozoal DNA, respectively. Used for Vulvovaginal candidiasis with concurrent trichomoniasis or bacterial vaginosis.

At a glance

Mechanism of action

Fluconazole is an azole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. Secnidazole is a nitroimidazole antiprotozoal that generates reactive intermediates that damage protozoal DNA and cellular structures. Together, they provide broad-spectrum coverage against fungal and protozoal infections.

Approved indications

• Vulvovaginal candidiasis with concurrent trichomoniasis or bacterial vaginosis

Common side effects

• Headache
• Nausea
• Abdominal pain
• Vulvovaginal irritation
• Metallic taste

Key clinical trials

• Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge (PHASE3)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Fluconazole and Secnidazole CI brief — competitive landscape report
• Fluconazole and Secnidazole updates RSS · CI watch RSS
• Universidad Nacional de Colombia portfolio CI