{"id":"fluconazole-and-secnidazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Vulvovaginal irritation"},{"rate":null,"effect":"Metallic taste"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluconazole is an azole antifungal that inhibits fungal cytochrome P450-dependent lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. Secnidazole is a nitroimidazole antiprotozoal that generates reactive intermediates that damage protozoal DNA and cellular structures. Together, they provide broad-spectrum coverage against fungal and protozoal infections.","oneSentence":"Fluconazole and secnidazole is a combination antifungal and antiprotozoal agent that inhibits fungal ergosterol synthesis and disrupts protozoal DNA, respectively.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:50.037Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vulvovaginal candidiasis with concurrent trichomoniasis or bacterial vaginosis"}]},"trialDetails":[{"nctId":"NCT02111629","phase":"PHASE3","title":"Safety and Clinical and Microbiological Efficacy of the Combination of Fluconazole and Secnidazole for the Treatment of Symptomatic Vaginal Discharge","status":"COMPLETED","sponsor":"Universidad Nacional de Colombia","startDate":"2012-05","conditions":"Vaginal Discharge","enrollment":118}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Fluconazole and Secnidazole","genericName":"Fluconazole and Secnidazole","companyName":"Universidad Nacional de Colombia","companyId":"universidad-nacional-de-colombia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fluconazole and secnidazole is a combination antifungal and antiprotozoal agent that inhibits fungal ergosterol synthesis and disrupts protozoal DNA, respectively. Used for Vulvovaginal candidiasis with concurrent trichomoniasis or bacterial vaginosis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}