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Flecainide or Sotalol or Propafenone
Flecainide or Sotalol or Propafenone is a Antiarrhythmic agents (Class I and Class III) Small molecule drug developed by Medtronic Cardiac Rhythm and Heart Failure. It is currently in Phase 3 development for Atrial fibrillation (maintenance of sinus rhythm or rate control), Paroxysmal supraventricular tachycardia, Ventricular arrhythmias. Also known as: Tambocor, Sotalol, Propafenone.
These antiarrhythmic drugs suppress abnormal heart rhythms by blocking sodium and/or potassium channels in cardiac tissue, slowing electrical conduction and prolonging the refractory period.
These antiarrhythmic drugs suppress abnormal heart rhythms by blocking sodium and/or potassium channels in cardiac tissue, slowing electrical conduction and prolonging the refractory period. Used for Atrial fibrillation (maintenance of sinus rhythm or rate control), Paroxysmal supraventricular tachycardia, Ventricular arrhythmias.
At a glance
| Generic name | Flecainide or Sotalol or Propafenone |
|---|---|
| Also known as | Tambocor, Sotalol, Propafenone |
| Sponsor | Medtronic Cardiac Rhythm and Heart Failure |
| Drug class | Antiarrhythmic agents (Class I and Class III) |
| Target | Cardiac sodium channels (Flecainide, Propafenone); cardiac potassium channels and beta-adrenergic receptors (Sotalol) |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Flecainide and Propafenone are Class IC antiarrhythmics that primarily block fast sodium channels, markedly slowing conduction velocity. Sotalol is a Class III antiarrhythmic with beta-blocking properties (Class II) that prolongs the action potential duration by blocking potassium channels. All three reduce the automaticity and conduction velocity of ectopic foci, thereby suppressing arrhythmias.
Approved indications
- Atrial fibrillation (maintenance of sinus rhythm or rate control)
- Paroxysmal supraventricular tachycardia
- Ventricular arrhythmias
- Prevention of arrhythmia recurrence in patients with implantable cardioverter-defibrillators
Common side effects
- Dizziness or lightheadedness
- Dyspnea or shortness of breath
- Fatigue
- Proarrhythmic effects (new or worsened arrhythmias)
- Bradycardia (Sotalol)
- QT prolongation (Sotalol)
- Tremor or visual disturbances (Flecainide)
Key clinical trials
- Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation (NA)
- EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment (NA)
- Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation (PHASE4)
- Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation (NA)
- A Prospective Study of Medical Therapy Against Cryoballoon Ablation in Symptomatic Recent Onset Persistent AF (PHASE4)
- First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation (PHASE3)
- Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drugs in Persistent Atrial Fibrillation (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Flecainide or Sotalol or Propafenone CI brief — competitive landscape report
- Flecainide or Sotalol or Propafenone updates RSS · CI watch RSS
- Medtronic Cardiac Rhythm and Heart Failure portfolio CI
Frequently asked questions about Flecainide or Sotalol or Propafenone
What is Flecainide or Sotalol or Propafenone?
How does Flecainide or Sotalol or Propafenone work?
What is Flecainide or Sotalol or Propafenone used for?
Who makes Flecainide or Sotalol or Propafenone?
Is Flecainide or Sotalol or Propafenone also known as anything else?
What drug class is Flecainide or Sotalol or Propafenone in?
What development phase is Flecainide or Sotalol or Propafenone in?
What are the side effects of Flecainide or Sotalol or Propafenone?
What does Flecainide or Sotalol or Propafenone target?
Related
- Drug class: All Antiarrhythmic agents (Class I and Class III) drugs
- Target: All drugs targeting Cardiac sodium channels (Flecainide, Propafenone); cardiac potassium channels and beta-adrenergic receptors (Sotalol)
- Manufacturer: Medtronic Cardiac Rhythm and Heart Failure — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Atrial fibrillation (maintenance of sinus rhythm or rate control)
- Indication: Drugs for Paroxysmal supraventricular tachycardia
- Indication: Drugs for Ventricular arrhythmias
- Also known as: Tambocor, Sotalol, Propafenone
- Compare: Flecainide or Sotalol or Propafenone vs similar drugs
- Pricing: Flecainide or Sotalol or Propafenone cost, discount & access