{"id":"flecainide-or-sotalol-or-propafenone","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Dizziness or lightheadedness"},{"rate":"5-15%","effect":"Dyspnea or shortness of breath"},{"rate":"5-10%","effect":"Fatigue"},{"rate":"1-5%","effect":"Proarrhythmic effects (new or worsened arrhythmias)"},{"rate":"5-15%","effect":"Bradycardia (Sotalol)"},{"rate":"variable","effect":"QT prolongation (Sotalol)"},{"rate":"1-5%","effect":"Tremor or visual disturbances (Flecainide)"}]},"_chembl":{"chemblId":"CHEMBL1200822","moleculeType":"Small molecule","molecularWeight":"474.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Flecainide and Propafenone are Class IC antiarrhythmics that primarily block fast sodium channels, markedly slowing conduction velocity. Sotalol is a Class III antiarrhythmic with beta-blocking properties (Class II) that prolongs the action potential duration by blocking potassium channels. All three reduce the automaticity and conduction velocity of ectopic foci, thereby suppressing arrhythmias.","oneSentence":"These antiarrhythmic drugs suppress abnormal heart rhythms by blocking sodium and/or potassium channels in cardiac tissue, slowing electrical conduction and prolonging the refractory period.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:12:44.228Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation (maintenance of sinus rhythm or rate control)"},{"name":"Paroxysmal supraventricular tachycardia"},{"name":"Ventricular arrhythmias"},{"name":"Prevention of arrhythmia recurrence in patients with implantable cardioverter-defibrillators"}]},"trialDetails":[{"nctId":"NCT07447297","phase":"NA","title":"Efficacy of Early Rhythm Control Therapy in Patients With Subclinical Atrial Fibrillation","status":"RECRUITING","sponsor":"Samsung Medical Center","startDate":"2024-01-02","conditions":"Atrial Fibrillation (AF), Diseases of the Circulatory System, Atrial Flutter","enrollment":520},{"nctId":"NCT05790707","phase":"NA","title":"EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment","status":"RECRUITING","sponsor":"Poitiers University Hospital","startDate":"2023-04-21","conditions":"Mild Cognitive Impairment, Persistent Atrial Fibrillation","enrollment":120},{"nctId":"NCT06783868","phase":"","title":"Assessing the Neurological Outcomes After Atrial Fibrillation Ablation for Rhythm Control","status":"NOT_YET_RECRUITING","sponsor":"Kansas City Heart Rhythm Research Foundation","startDate":"2025-10","conditions":"Atrial Fibrillation, Stroke","enrollment":100},{"nctId":"NCT00540787","phase":"PHASE4","title":"A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation","status":"COMPLETED","sponsor":"Biosense Webster, Inc.","startDate":"2003-08-01","conditions":"Paroxysmal Atrial Fibrillation","enrollment":112},{"nctId":"NCT02459574","phase":"NA","title":"Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation","status":"COMPLETED","sponsor":"Imperial College London","startDate":"2015-05-01","conditions":"Heart Failure, Recurrent Atrial Fibrillation","enrollment":321},{"nctId":"NCT02389218","phase":"PHASE4","title":"A Prospective Study of Medical Therapy Against Cryoballoon Ablation in Symptomatic Recent Onset Persistent AF","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2015-03-03","conditions":"Atrial Fibrillation","enrollment":13},{"nctId":"NCT05939076","phase":"PHASE3","title":"First-line Cryoablation for Early Treatment of Persistent Atrial Fibrillation","status":"NOT_YET_RECRUITING","sponsor":"Region Örebro County","startDate":"2023-08-21","conditions":"Atrial Fibrillation, Persistent","enrollment":220},{"nctId":"NCT03437356","phase":"NA","title":"Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drugs in Persistent Atrial Fibrillation","status":"COMPLETED","sponsor":"AZ Sint-Jan AV","startDate":"2018-02-26","conditions":"Atrial Fibrillation","enrollment":210},{"nctId":"NCT00911508","phase":"NA","title":"Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2009-11-13","conditions":"Atrial Fibrillation, Arrhythmia","enrollment":2204},{"nctId":"NCT00523978","phase":"PHASE3","title":"A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation","status":"COMPLETED","sponsor":"Medtronic Cardiac Rhythm and Heart Failure","startDate":"2006-10","conditions":"Paroxysmal Atrial Fibrillation","enrollment":245},{"nctId":"NCT01477983","phase":"PHASE4","title":"Kansai Plus Atrial Fibrillation Trial","status":"COMPLETED","sponsor":"Kyoto University, Graduate School of Medicine","startDate":"2011-11","conditions":"Atrial Fibrillation","enrollment":2113},{"nctId":"NCT02294955","phase":"NA","title":"Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)","status":"UNKNOWN","sponsor":"Uppsala University Hospital","startDate":"2008-05","conditions":"Atrial Fibrillation, Quality of Life","enrollment":152},{"nctId":"NCT01505296","phase":"PHASE4","title":"Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation","status":"WITHDRAWN","sponsor":"Valley Health System","startDate":"2011-12","conditions":"Atrial Fibrillation","enrollment":""},{"nctId":"NCT00589303","phase":"PHASE3","title":"AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study","status":"TERMINATED","sponsor":"Mayo Clinic","startDate":"2007-12","conditions":"Atrial Fibrillation, Heart Failure","enrollment":27},{"nctId":"NCT01780311","phase":"PHASE4","title":"Catheter Ablation Versus Antiarrhythmic Drugs for Outflow Tract Ventricular ARrhythmias","status":"UNKNOWN","sponsor":"Ospedale San Donato","startDate":"2013-01","conditions":"Ventricular Tachycardia, Ventricular Premature Complexes","enrollment":""},{"nctId":"NCT00578617","phase":"NA","title":"Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2006-09","conditions":"Atrial Fibrillation, Arrhythmia","enrollment":60},{"nctId":"NCT01709682","phase":"PHASE2","title":"A Comparison of the Drug Therapy Versus Re-Ablation","status":"COMPLETED","sponsor":"Meshalkin Research Institute of Pathology of Circulation","startDate":"2007-11","conditions":"Paroxysmal Atrial Fibrillation, Failed First Radiofrequency Ablation Procedure","enrollment":154},{"nctId":"NCT00392106","phase":"PHASE3","title":"High Intensity Focused Ultrasound (HIFU) Ablation System Study","status":"SUSPENDED","sponsor":"ProRhythm, Inc.","startDate":"2006-04","conditions":"Atrial Fibrillation","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Tambocor","Sotalol","Propafenone"],"phase":"phase_3","status":"active","brandName":"Flecainide or Sotalol or Propafenone","genericName":"Flecainide or Sotalol or Propafenone","companyName":"Medtronic Cardiac Rhythm and Heart Failure","companyId":"medtronic-cardiac-rhythm-and-heart-failure","modality":"Small molecule","firstApprovalDate":"","aiSummary":"These antiarrhythmic drugs suppress abnormal heart rhythms by blocking sodium and/or potassium channels in cardiac tissue, slowing electrical conduction and prolonging the refractory period. Used for Atrial fibrillation (maintenance of sinus rhythm or rate control), Paroxysmal supraventricular tachycardia, Ventricular arrhythmias.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}