Last reviewed · How we verify
Fibrin Sealant 2 (FS2)
Fibrin Sealant 2 is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgical procedures.
Fibrin Sealant 2 is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgical procedures. Used for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.
At a glance
| Generic name | Fibrin Sealant 2 (FS2) |
|---|---|
| Also known as | CROSSEAL*, EVICEL*, tissue adhesive |
| Sponsor | Ethicon, Inc. |
| Drug class | Fibrin sealant / Hemostatic agent |
| Target | Fibrinogen and thrombin (coagulation cascade) |
| Modality | Small molecule |
| Therapeutic area | Surgery / Hemostasis |
| Phase | Phase 3 |
Mechanism of action
FS2 combines human fibrinogen and thrombin to create a cross-linked fibrin matrix at the site of application, mimicking the final stages of the coagulation cascade. This provides rapid hemostasis and tissue adhesion, reducing blood loss during surgery and potentially improving wound healing. The fibrin scaffold is gradually absorbed and replaced by natural tissue remodeling.
Approved indications
- Hemostasis and tissue sealing during general surgery
- Hemostasis during cardiovascular surgery
- Hemostasis during orthopedic surgery
Common side effects
- Allergic reaction
- Infection at application site
- Seroma formation
- Hematoma
Key clinical trials
- Evaluation of Fibrin Sealant 2 in Retroperitoneal or Intra-Abdominal Surgery (PHASE3)
- Evaluation of Fibrin Sealant 2 in Vascular Surgical Procedures (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fibrin Sealant 2 (FS2) CI brief — competitive landscape report
- Fibrin Sealant 2 (FS2) updates RSS · CI watch RSS
- Ethicon, Inc. portfolio CI