{"id":"fibrin-sealant-2-fs2","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Infection at application site"},{"rate":null,"effect":"Seroma formation"},{"rate":null,"effect":"Hematoma"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"FS2 combines human fibrinogen and thrombin to create a cross-linked fibrin matrix at the site of application, mimicking the final stages of the coagulation cascade. This provides rapid hemostasis and tissue adhesion, reducing blood loss during surgery and potentially improving wound healing. The fibrin scaffold is gradually absorbed and replaced by natural tissue remodeling.","oneSentence":"Fibrin Sealant 2 is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgical procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:12:41.527Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and tissue sealing during general surgery"},{"name":"Hemostasis during cardiovascular surgery"},{"name":"Hemostasis during orthopedic surgery"}]},"trialDetails":[{"nctId":"NCT00307515","phase":"PHASE3","title":"Evaluation of Fibrin Sealant 2 in Retroperitoneal or Intra-Abdominal Surgery","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2006-02","conditions":"Blood Loss, Surgical","enrollment":135},{"nctId":"NCT00154141","phase":"PHASE3","title":"Evaluation of Fibrin Sealant 2 in Vascular Surgical Procedures","status":"COMPLETED","sponsor":"Ethicon, Inc.","startDate":"2005-06","conditions":"Peripheral Vascular Disease","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CROSSEAL*","EVICEL*","tissue adhesive"],"phase":"phase_3","status":"active","brandName":"Fibrin Sealant 2 (FS2)","genericName":"Fibrin Sealant 2 (FS2)","companyName":"Ethicon, Inc.","companyId":"ethicon-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fibrin Sealant 2 is a topical hemostatic agent that forms a fibrin clot to seal wounds and control bleeding during surgical procedures. Used for Hemostasis and tissue sealing during general surgery, Hemostasis during cardiovascular surgery, Hemostasis during orthopedic surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}