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Fentanyl/Atropine/Succinylcholine
This is a combination of three drugs used in anesthesia: fentanyl (opioid analgesic), atropine (anticholinergic), and succinylcholine (depolarizing neuromuscular blocker) that together provide analgesia, prevent vagal responses, and induce muscle paralysis.
This is a combination of three drugs used in anesthesia: fentanyl (opioid analgesic), atropine (anticholinergic), and succinylcholine (depolarizing neuromuscular blocker) that together provide analgesia, prevent vagal responses, and induce muscle paralysis. Used for Induction and maintenance of general anesthesia, Facilitation of endotracheal intubation, Analgesia and sedation during surgical procedures.
At a glance
| Generic name | Fentanyl/Atropine/Succinylcholine |
|---|---|
| Sponsor | King Saud University |
| Drug class | Anesthetic combination (opioid + anticholinergic + neuromuscular blocker) |
| Target | Mu-opioid receptor (fentanyl); muscarinic acetylcholine receptors (atropine); nicotinic acetylcholine receptors at neuromuscular junction (succinylcholine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Fentanyl acts as a potent mu-opioid receptor agonist to provide analgesia and sedation. Atropine blocks muscarinic acetylcholine receptors to prevent bradycardia and excessive salivation caused by succinylcholine. Succinylcholine acts as a depolarizing agent at the neuromuscular junction, causing sustained depolarization that leads to muscle paralysis necessary for intubation and mechanical ventilation.
Approved indications
- Induction and maintenance of general anesthesia
- Facilitation of endotracheal intubation
- Analgesia and sedation during surgical procedures
Common side effects
- Bradycardia
- Hypotension
- Respiratory depression
- Muscle rigidity
- Postoperative nausea and vomiting
- Malignant hyperthermia (succinylcholine)
Key clinical trials
- Effectiveness of Sugammadex in LMS Surgery (PHASE4)
- Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation (PHASE4)
- Remifentanil and Atropine for Intubation in Neonates (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fentanyl/Atropine/Succinylcholine CI brief — competitive landscape report
- Fentanyl/Atropine/Succinylcholine updates RSS · CI watch RSS
- King Saud University portfolio CI