{"id":"fentanyl-atropine-succinylcholine","safety":{"commonSideEffects":[{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Muscle rigidity"},{"rate":null,"effect":"Postoperative nausea and vomiting"},{"rate":"rare","effect":"Malignant hyperthermia (succinylcholine)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl acts as a potent mu-opioid receptor agonist to provide analgesia and sedation. Atropine blocks muscarinic acetylcholine receptors to prevent bradycardia and excessive salivation caused by succinylcholine. Succinylcholine acts as a depolarizing agent at the neuromuscular junction, causing sustained depolarization that leads to muscle paralysis necessary for intubation and mechanical ventilation.","oneSentence":"This is a combination of three drugs used in anesthesia: fentanyl (opioid analgesic), atropine (anticholinergic), and succinylcholine (depolarizing neuromuscular blocker) that together provide analgesia, prevent vagal responses, and induce muscle paralysis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:45.669Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Facilitation of endotracheal intubation"},{"name":"Analgesia and sedation during surgical procedures"}]},"trialDetails":[{"nctId":"NCT02329964","phase":"PHASE4","title":"Effectiveness of Sugammadex in LMS Surgery","status":"UNKNOWN","sponsor":"Korea University Anam Hospital","startDate":"2015-02","conditions":"Muscle Relaxation","enrollment":80},{"nctId":"NCT01595399","phase":"PHASE4","title":"Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation","status":"UNKNOWN","sponsor":"University of Manitoba","startDate":"2012-04","conditions":"Bradycardia, Hypoxemia","enrollment":70},{"nctId":"NCT00815048","phase":"PHASE4","title":"Remifentanil and Atropine for Intubation in Neonates","status":"COMPLETED","sponsor":"King Saud University","startDate":"2006-01","conditions":"Endotracheal Intubation","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fentanyl/Atropine/Succinylcholine","genericName":"Fentanyl/Atropine/Succinylcholine","companyName":"King Saud University","companyId":"king-saud-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three drugs used in anesthesia: fentanyl (opioid analgesic), atropine (anticholinergic), and succinylcholine (depolarizing neuromuscular blocker) that together provide analgesia, prevent vagal responses, and induce muscle paralysis. Used for Induction and maintenance of general anesthesia, Facilitation of endotracheal intubation, Analgesia and sedation during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}