Last reviewed · How we verify
Femara
At a glance
| Generic name | Femara |
|---|---|
| Also known as | Letrozole |
| Sponsor | M.D. Anderson Cancer Center |
| Target | Cytochrome P450 11B2, mitochondrial, Aromatase, Cytochrome P450 11B1, mitochondrial |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | discontinued |
Approved indications
- Controlled ovarian stimulation
- Early Breast Cancer Hormone Receptor Positive and Postmenopausal
- Hormone receptor positive malignant neoplasm of breast
- Induction of ovulation in polycystic ovarian syndrome
- Induction of ovulation in unexplained infertility
Common side effects
Key clinical trials
- A Phase 1b Study of Palbociclib, Letrozole and Venetoclax in ER and BCL-2 Positive Locally Advanced or Metastatic Breast Cancer (Phase 1)
- Trial of Letrozole in Lymphangioleiomyomatosis (Phase 2)
- Effect of Light Alcohol Intake on Sex Hormone Levels Among Postmenopausal Women With ER+ Breast Cancer on Aromatase Inhibitor Therapy: The Alcohol and Breast Cancer (ABC) Trial (NA)
- Comparison of Adjuvant Monotherapy With Endocrine Therapy or Accelerated Partial Breast Irradiation Following Lumpectomy for Low Risk Breast Cancer Patients Over 65 (CAMERAN) (Phase 2)
- Association of Survival With Maintenance Therapy in Patients With Metastatic Breast Cancer After First-line Chemotherapy (N/A)
- Investigating Cognitive Function for Patients Participating in the BIG Trial 1-98 in Select Centers (Phase 3)
- Extended Endocrine Therapy for Premenopausal Women With Breast Cancer (Phase 2)
- CIMER: Combined Immunotherapies in Metastatic ER+ Breast Cancer (Phase 2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Femara CI brief — competitive landscape report
- Femara updates RSS · CI watch RSS
- M.D. Anderson Cancer Center portfolio CI