Last reviewed · How we verify
Experimental - 4% Sodium Bicarbonate
Sodium bicarbonate neutralizes gastric acid and raises blood pH to treat acidosis and acid-related conditions.
Sodium bicarbonate neutralizes gastric acid and raises blood pH to treat acidosis and acid-related conditions. Used for Metabolic acidosis, Gastric acid neutralization, Urine alkalinization.
At a glance
| Generic name | Experimental - 4% Sodium Bicarbonate |
|---|---|
| Sponsor | Baptist Health South Florida |
| Drug class | Antacid / Alkalinizing agent |
| Modality | Small molecule |
| Therapeutic area | Gastroenterology / Critical Care / Metabolic Disorders |
| Phase | FDA-approved |
Mechanism of action
Sodium bicarbonate is a weak base that reacts with hydrochloric acid in the stomach to form sodium chloride, water, and carbon dioxide, thereby reducing gastric acidity. Systemically, it increases serum bicarbonate concentration and raises blood pH, making it useful in treating metabolic acidosis and alkalinizing urine. The 4% formulation is typically used for intravenous administration in acute acidosis management.
Approved indications
- Metabolic acidosis
- Gastric acid neutralization
- Urine alkalinization
Common side effects
- Metabolic alkalosis
- Hypernatremia
- Hypokalemia
- Nausea
Key clinical trials
- Comparative Evaluation of the Effect of pH Adjustment of the Solution of Articaine With Epinephrine on the Efficacy of Jet Anesthesia (NA)
- Effect of Sodium Bicarbonate, Saline and Black Mulberry Syrup on Degree of Oral Mucositis in Children Receiving Chemotherapy (NA)
- Shigella CVD 30000: Study of Responses to Vaccination With Shigella Vaccine (PHASE2)
- A Trial Comparing Single Agent Melphalan to Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) as a Preparative Regimen for Patients With Multiple Myeloma Undergoing High Dose Therapy Followed by Autologous Stem Cell Reinfusion (PHASE2)
- Effect of Urine Alkalinazation on Urinary Inflammatory Markers in Patients With Cystinuria
- The Impact of Neut During Potassium Chloride Replacement on Pain and Incidence of Phlebitis (PHASE4)
- Effect of Black Mulberry Lollipop on Prevention of Oral Mucositis in Children (NA)
- Dose-Finding Study of Lyophilized Shigella Sonnei 53G Challenge Strain (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: