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etomidate, fentanyl, and lidocaine
This is a combination of three agents that work together: etomidate provides rapid sedation via GABA-A receptor agonism, fentanyl provides analgesia via opioid receptor agonism, and lidocaine provides local anesthesia via sodium channel blockade.
This is a combination of three agents that work together: etomidate provides rapid sedation via GABA-A receptor agonism, fentanyl provides analgesia via opioid receptor agonism, and lidocaine provides local anesthesia via sodium channel blockade. Used for Rapid sequence intubation and induction of general anesthesia, Procedural sedation and analgesia.
At a glance
| Generic name | etomidate, fentanyl, and lidocaine |
|---|---|
| Sponsor | Drexel University College of Medicine |
| Drug class | Anesthetic combination (hypnotic + opioid + local anesthetic) |
| Target | GABA-A receptor (etomidate), mu opioid receptor (fentanyl), voltage-gated sodium channels (lidocaine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Etomidate is a non-barbiturate hypnotic that enhances inhibitory GABA-A signaling in the central nervous system to induce unconsciousness. Fentanyl is a potent synthetic opioid agonist that binds mu opioid receptors to provide analgesia and sedation. Lidocaine is a local anesthetic that blocks voltage-gated sodium channels to prevent pain signal transmission. Together, these agents provide rapid sequence intubation anesthesia with analgesia and local pain control.
Approved indications
- Rapid sequence intubation and induction of general anesthesia
- Procedural sedation and analgesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Adrenal suppression (etomidate-related)
Key clinical trials
- SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke (PHASE4)
- Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES (NA)
- Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ) (PHASE4)
- Etomidate Versus Propofol in CABG Surgery (PHASE4)
- Heart Rate Variability to Quantify General Anesthesia Depth
- Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions (PHASE4)
- Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |