{"id":"etomidate-fentanyl-and-lidocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Adrenal suppression (etomidate-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Etomidate is a non-barbiturate hypnotic that enhances inhibitory GABA-A signaling in the central nervous system to induce unconsciousness. Fentanyl is a potent synthetic opioid agonist that binds mu opioid receptors to provide analgesia and sedation. Lidocaine is a local anesthetic that blocks voltage-gated sodium channels to prevent pain signal transmission. Together, these agents provide rapid sequence intubation anesthesia with analgesia and local pain control.","oneSentence":"This is a combination of three agents that work together: etomidate provides rapid sedation via GABA-A receptor agonism, fentanyl provides analgesia via opioid receptor agonism, and lidocaine provides local anesthesia via sodium channel blockade.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:45:59.735Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rapid sequence intubation and induction of general anesthesia"},{"name":"Procedural sedation and analgesia"}]},"trialDetails":[{"nctId":"NCT03263117","phase":"PHASE4","title":"SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke","status":"COMPLETED","sponsor":"The University of Texas Health Science Center, Houston","startDate":"2018-07-01","conditions":"Stroke","enrollment":260},{"nctId":"NCT05688943","phase":"NA","title":"Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES","status":"ENROLLING_BY_INVITATION","sponsor":"University of Kansas Medical Center","startDate":"2023-03-01","conditions":"Anesthesia, Tubal Ligation","enrollment":20},{"nctId":"NCT05899127","phase":"PHASE4","title":"Relationship Between Lidocaine and Serum Orphanin FQ (N/OFQ)","status":"UNKNOWN","sponsor":"Second Hospital of Shanxi Medical University","startDate":"2023-07-22","conditions":"Stress Reaction","enrollment":80},{"nctId":"NCT06068764","phase":"PHASE4","title":"Etomidate Versus Propofol in CABG Surgery","status":"RECRUITING","sponsor":"Hartford Hospital","startDate":"2023-12-05","conditions":"Coronary Artery Disease","enrollment":300},{"nctId":"NCT04788732","phase":"","title":"Heart Rate Variability to Quantify General Anesthesia Depth","status":"UNKNOWN","sponsor":"University of Sao Paulo","startDate":"2021-01-04","conditions":"Anesthesia Awareness","enrollment":200},{"nctId":"NCT00596050","phase":"PHASE4","title":"Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions","status":"COMPLETED","sponsor":"Drexel University College of Medicine","startDate":"2006-08","conditions":"Conscious Sedation Failure During Procedure","enrollment":50},{"nctId":"NCT02141737","phase":"PHASE4","title":"Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia","status":"UNKNOWN","sponsor":"Tang-Du Hospital","startDate":"2014-05","conditions":"General Anesthesia","enrollment":272}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"etomidate, fentanyl, and lidocaine","genericName":"etomidate, fentanyl, and lidocaine","companyName":"Drexel University College of Medicine","companyId":"drexel-university-college-of-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of three agents that work together: etomidate provides rapid sedation via GABA-A receptor agonism, fentanyl provides analgesia via opioid receptor agonism, and lidocaine provides local anesthesia via sodium channel blockade. Used for Rapid sequence intubation and induction of general anesthesia, Procedural sedation and analgesia.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}