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Ethambutol Oral Product
Ethambutol Oral Product is a Antituberculous agent Small molecule drug developed by Wits Health Consortium (Pty) Ltd. It is currently in Phase 3 development for Tuberculosis (pulmonary and extrapulmonary), Mycobacterium avium complex (MAC) infection.
Ethambutol inhibits mycobacterial arabinosyl transferases, disrupting the synthesis of the mycobacterial cell wall component arabinogalactan.
Ethambutol inhibits mycobacterial arabinosyl transferases, disrupting the synthesis of the mycobacterial cell wall component arabinogalactan. Used for Tuberculosis (pulmonary and extrapulmonary), Mycobacterium avium complex (MAC) infection.
At a glance
| Generic name | Ethambutol Oral Product |
|---|---|
| Sponsor | Wits Health Consortium (Pty) Ltd |
| Drug class | Antituberculous agent |
| Target | Arabinosyl transferases (EmbA, EmbB, EmbC) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Ethambutol is a first-line antituberculous agent that selectively inhibits enzymes involved in arabinogalactan biosynthesis in mycobacteria. By disrupting cell wall integrity, it is bacteriostatic against Mycobacterium tuberculosis and other mycobacterial species. It is typically used in combination with other antituberculous drugs to prevent resistance.
Approved indications
- Tuberculosis (pulmonary and extrapulmonary)
- Mycobacterium avium complex (MAC) infection
Common side effects
- Optic neuritis
- Color blindness (red-green)
- Peripheral neuropathy
- Hyperuricemia
- Gastrointestinal disturbance
- Headache
Key clinical trials
- Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial (PHASE2)
- Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease (PHASE2, PHASE3)
- Phase 2 Trial to Evaluate the Safety and Tolerability and Early Bactericidal Activity of RESP30TB in Tuberculosis (PHASE2)
- Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- PanACEA - STEP2C -01 (PHASE2)
- Pharmacokinetic and Pharmacodynamic Study of High-Dose Rifapentine and Moxifloxacin for Treatment of Tuberculosis (PHASE3)
- Short-course Regimens for the Treatment of Pulmonary Tuberculosis (PHASE2, PHASE3)
- Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ethambutol Oral Product CI brief — competitive landscape report
- Ethambutol Oral Product updates RSS · CI watch RSS
- Wits Health Consortium (Pty) Ltd portfolio CI
Frequently asked questions about Ethambutol Oral Product
What is Ethambutol Oral Product?
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What does Ethambutol Oral Product target?
Related
- Drug class: All Antituberculous agent drugs
- Target: All drugs targeting Arabinosyl transferases (EmbA, EmbB, EmbC)
- Manufacturer: Wits Health Consortium (Pty) Ltd — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Tuberculosis (pulmonary and extrapulmonary)
- Indication: Drugs for Mycobacterium avium complex (MAC) infection
- Compare: Ethambutol Oral Product vs similar drugs
- Pricing: Ethambutol Oral Product cost, discount & access