{"id":"ethambutol-oral-product","safety":{"commonSideEffects":[{"rate":"1-2","effect":"Optic neuritis"},{"rate":"1-2","effect":"Color blindness (red-green)"},{"rate":null,"effect":"Peripheral neuropathy"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ethambutol is a first-line antituberculous agent that selectively inhibits enzymes involved in arabinogalactan biosynthesis in mycobacteria. By disrupting cell wall integrity, it is bacteriostatic against Mycobacterium tuberculosis and other mycobacterial species. It is typically used in combination with other antituberculous drugs to prevent resistance.","oneSentence":"Ethambutol inhibits mycobacterial arabinosyl transferases, disrupting the synthesis of the mycobacterial cell wall component arabinogalactan.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:29.994Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tuberculosis (pulmonary and extrapulmonary)"},{"name":"Mycobacterium avium complex (MAC) infection"}]},"trialDetails":[{"nctId":"NCT07485010","phase":"PHASE2","title":"Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial","status":"NOT_YET_RECRUITING","sponsor":"The University of Queensland","startDate":"2027-04","conditions":"Mycobacterium Abscessus 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Used for Tuberculosis (pulmonary and extrapulmonary), Mycobacterium avium complex (MAC) infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}