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Estradiol transdermal one 90 μL spray

Lumara Health, Inc. · Phase 3 active Small molecule

Estradiol transdermal one 90 μL spray is a Hormone replacement therapy (HRT) / Estrogen Small molecule drug developed by Lumara Health, Inc.. It is currently in Phase 3 development for Vasomotor symptoms associated with menopause, Moderate to severe menopausal hot flashes and night sweats.

Estradiol transdermal spray delivers the hormone estradiol through the skin to replace or supplement endogenous estrogen levels.

Estradiol transdermal spray delivers the hormone estradiol through the skin to replace or supplement endogenous estrogen levels. Used for Vasomotor symptoms associated with menopause, Moderate to severe menopausal hot flashes and night sweats.

At a glance

Generic nameEstradiol transdermal one 90 μL spray
SponsorLumara Health, Inc.
Drug classHormone replacement therapy (HRT) / Estrogen
TargetEstrogen receptor alpha (ERα), Estrogen receptor beta (ERβ)
ModalitySmall molecule
Therapeutic areaEndocrinology / Women's Health
PhasePhase 3

Mechanism of action

Estradiol is a naturally occurring estrogen that binds to estrogen receptors (ERα and ERβ) throughout the body, modulating gene expression in target tissues. The transdermal spray formulation allows for continuous systemic absorption through the skin, bypassing first-pass hepatic metabolism and providing steady-state hormone levels. This mechanism is used to alleviate symptoms of estrogen deficiency and support hormonal balance in menopausal and postmenopausal women.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about Estradiol transdermal one 90 μL spray

What is Estradiol transdermal one 90 μL spray?

Estradiol transdermal one 90 μL spray is a Hormone replacement therapy (HRT) / Estrogen drug developed by Lumara Health, Inc., indicated for Vasomotor symptoms associated with menopause, Moderate to severe menopausal hot flashes and night sweats.

How does Estradiol transdermal one 90 μL spray work?

Estradiol transdermal spray delivers the hormone estradiol through the skin to replace or supplement endogenous estrogen levels.

What is Estradiol transdermal one 90 μL spray used for?

Estradiol transdermal one 90 μL spray is indicated for Vasomotor symptoms associated with menopause, Moderate to severe menopausal hot flashes and night sweats.

Who makes Estradiol transdermal one 90 μL spray?

Estradiol transdermal one 90 μL spray is developed by Lumara Health, Inc. (see full Lumara Health, Inc. pipeline at /company/lumara-health-inc).

What drug class is Estradiol transdermal one 90 μL spray in?

Estradiol transdermal one 90 μL spray belongs to the Hormone replacement therapy (HRT) / Estrogen class. See all Hormone replacement therapy (HRT) / Estrogen drugs at /class/hormone-replacement-therapy-hrt-estrogen.

What development phase is Estradiol transdermal one 90 μL spray in?

Estradiol transdermal one 90 μL spray is in Phase 3.

What are the side effects of Estradiol transdermal one 90 μL spray?

Common side effects of Estradiol transdermal one 90 μL spray include Breast tenderness, Headache, Nausea, Application site reactions, Vaginal bleeding or spotting.

What does Estradiol transdermal one 90 μL spray target?

Estradiol transdermal one 90 μL spray targets Estrogen receptor alpha (ERα), Estrogen receptor beta (ERβ) and is a Hormone replacement therapy (HRT) / Estrogen.

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