{"id":"estradiol-transdermal-one-90-l-spray","safety":{"commonSideEffects":[{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Application site reactions"},{"rate":null,"effect":"Vaginal bleeding or spotting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Estradiol is a naturally occurring estrogen that binds to estrogen receptors (ERα and ERβ) throughout the body, modulating gene expression in target tissues. The transdermal spray formulation allows for continuous systemic absorption through the skin, bypassing first-pass hepatic metabolism and providing steady-state hormone levels. This mechanism is used to alleviate symptoms of estrogen deficiency and support hormonal balance in menopausal and postmenopausal women.","oneSentence":"Estradiol transdermal spray delivers the hormone estradiol through the skin to replace or supplement endogenous estrogen levels.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:11:39.155Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vasomotor symptoms associated with menopause"},{"name":"Moderate to severe menopausal hot flashes and night sweats"}]},"trialDetails":[{"nctId":"NCT01389102","phase":"PHASE3","title":"Estradiol Transdermal Spray in the Treatment of Vasomotor Symptoms","status":"COMPLETED","sponsor":"Lumara Health, Inc.","startDate":"2004-12","conditions":"Hot Flashes","enrollment":454}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Estradiol transdermal one 90 μL spray","genericName":"Estradiol transdermal one 90 μL spray","companyName":"Lumara Health, Inc.","companyId":"lumara-health-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Estradiol transdermal spray delivers the hormone estradiol through the skin to replace or supplement endogenous estrogen levels. Used for Vasomotor symptoms associated with menopause, Moderate to severe menopausal hot flashes and night sweats.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}