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EscharEx
EscharEx is a topical enzyme therapy that degrades necrotic tissue.
EscharEx is a topical enzyme therapy that degrades necrotic tissue. Used for Treatment of diabetic foot ulcers, Treatment of venous leg ulcers.
At a glance
| Generic name | EscharEx |
|---|---|
| Sponsor | MediWound Ltd |
| Drug class | Enzyme therapy |
| Modality | Small molecule |
| Therapeutic area | Wound care |
| Phase | Phase 2 |
Mechanism of action
It works by breaking down dead tissue, promoting wound healing and reducing the risk of infection. This process helps to create a clean wound bed, allowing for more effective treatment and potentially reducing the need for surgical debridement.
Approved indications
- Treatment of diabetic foot ulcers
- Treatment of venous leg ulcers
Common side effects
- Skin irritation
- Allergic reactions
Key clinical trials
- A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE) (PHASE3)
- Clinical Study to Evaluate the Safety and the Efficacy of EscharEx Drug Product (EX-03 Formulation) and Its Placebo Compared to Collagenase, Non-surgical Standard of Care, in Patients With Venous Leg Ulcers (PHASE2)
- A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers (PHASE2)
- A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers (PHASE2)
- A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma (PHASE1, PHASE2)
- Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |