{"id":"escharex","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"},{"rate":"null","effect":"Allergic reactions"}]},"_chembl":{"chemblId":"CHEMBL4298054","moleculeType":"Enzyme"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by breaking down dead tissue, promoting wound healing and reducing the risk of infection. This process helps to create a clean wound bed, allowing for more effective treatment and potentially reducing the need for surgical debridement.","oneSentence":"EscharEx is a topical enzyme therapy that degrades necrotic tissue.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:51:47.848Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of diabetic foot ulcers"},{"name":"Treatment of venous leg ulcers"}]},"trialDetails":[{"nctId":"NCT06568627","phase":"PHASE3","title":"A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE)","status":"RECRUITING","sponsor":"MediWound Ltd","startDate":"2025-06-01","conditions":"Venous Leg Ulcer (VLU)","enrollment":216},{"nctId":"NCT06690177","phase":"PHASE2","title":"Clinical Study to Evaluate the Safety and the Efficacy of EscharEx Drug Product (EX-03 Formulation) and Its Placebo Compared to Collagenase, Non-surgical Standard of Care, in Patients With Venous Leg Ulcers","status":"NOT_YET_RECRUITING","sponsor":"MediWound Ltd","startDate":"2025-04-30","conditions":"Venus Leg Ulcers","enrollment":45},{"nctId":"NCT03588130","phase":"PHASE2","title":"A Study to Evaluate the Safety and the Efficacy of EscharEx (EX-02 Formulation) in Debridement of Venous Leg Ulcers","status":"COMPLETED","sponsor":"MediWound Ltd","startDate":"2019-12-02","conditions":"Venous Leg Ulcer","enrollment":120},{"nctId":"NCT04817228","phase":"PHASE2","title":"A Study to Evaluate the Clinical Performance, Safety and Pharmacology Effect of EscharEx in Patients With Lower Leg Ulcers","status":"COMPLETED","sponsor":"MediWound Ltd","startDate":"2021-04-21","conditions":"Venous Leg Ulcer, Diabetic Foot Ulcer","enrollment":12},{"nctId":"NCT05157763","phase":"PHASE1, PHASE2","title":"A Study to Evaluate the Safety and Efficacy of EscharEx (EX-02) in the Treatment of Basal Cell Carcinoma","status":"RECRUITING","sponsor":"MediWound Ltd","startDate":"2021-06-30","conditions":"Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma","enrollment":32},{"nctId":"NCT02020746","phase":"PHASE2","title":"Efficacy and Safety Study of EscharEx to Treat (Debride) Hard to Heal Wounds","status":"COMPLETED","sponsor":"MediWound Ltd","startDate":"2014-07-24","conditions":"Hard to Heal Wounds, Venous Leg Ulcers, Diabetic Lower Extremity Ulcers","enrollment":111}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"EscharEx","genericName":"EscharEx","companyName":"MediWound Ltd","companyId":"mediwound-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EscharEx is a topical enzyme therapy that degrades necrotic tissue. Used for Treatment of diabetic foot ulcers, Treatment of venous leg ulcers.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}