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equimolar oxygen-nitrous oxide mixture
An equimolar mixture of oxygen and nitrous oxide provides analgesia and anxiolysis through nitrous oxide's effects on central nervous system receptors while maintaining adequate oxygenation.
An equimolar mixture of oxygen and nitrous oxide provides analgesia and anxiolysis through nitrous oxide's effects on central nervous system receptors while maintaining adequate oxygenation. Used for Acute pain relief in emergency settings, Anxiolysis and analgesia during minor procedures, Procedural sedation.
At a glance
| Generic name | equimolar oxygen-nitrous oxide mixture |
|---|---|
| Sponsor | Centre Hospitalier Universitaire de Nīmes |
| Drug class | Inhalational anesthetic/analgesic mixture |
| Target | NMDA receptor antagonist (nitrous oxide component) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Acute Pain Management |
| Phase | FDA-approved |
Mechanism of action
Nitrous oxide acts as a dissociative anesthetic and analgesic by modulating NMDA receptors and other central pathways, while the equimolar oxygen component (50% each) ensures adequate oxygenation and reduces the risk of hypoxia. This combination is commonly used for acute pain relief and anxiolysis in emergency and procedural settings, allowing rapid onset and offset due to nitrous oxide's rapid kinetics.
Approved indications
- Acute pain relief in emergency settings
- Anxiolysis and analgesia during minor procedures
- Procedural sedation
Common side effects
- Dizziness
- Nausea
- Euphoria
- Dissociation
- Headache
Key clinical trials
- Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration (NA)
- Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children. (NA)
- Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote) (NA)
- Nitrous Oxide for Late-Life Depression - PROTO-BRAIN (NA)
- Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder (PHASE4)
- Pediatric Emergency Suture Care: a Trial Comparing the Analgesic Efficacy of Hypnosis Versus MEOPA (PHASE4)
- QUALHYBOM Hypnosis Versus Equimolar Mixture of Oxygen and Nitrous Oxide (MEOPA) During a Bone Marrow Biopsy: a Clinical, Controlled, Randomized, Multicenter Study (NA)
- Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial- (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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