{"id":"equimolar-oxygen-nitrous-oxide-mixture","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Euphoria"},{"rate":null,"effect":"Dissociation"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Nitrous oxide acts as a dissociative anesthetic and analgesic by modulating NMDA receptors and other central pathways, while the equimolar oxygen component (50% each) ensures adequate oxygenation and reduces the risk of hypoxia. This combination is commonly used for acute pain relief and anxiolysis in emergency and procedural settings, allowing rapid onset and offset due to nitrous oxide's rapid kinetics.","oneSentence":"An equimolar mixture of oxygen and nitrous oxide provides analgesia and anxiolysis through nitrous oxide's effects on central nervous system receptors while maintaining adequate oxygenation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:45:40.734Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain relief in emergency settings"},{"name":"Anxiolysis and analgesia during minor procedures"},{"name":"Procedural sedation"}]},"trialDetails":[{"nctId":"NCT06928740","phase":"NA","title":"Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration","status":"RECRUITING","sponsor":"Centre Hospitalier Universitaire de Nīmes","startDate":"2025-10-21","conditions":"Low Back Pain, Anxiety","enrollment":128},{"nctId":"NCT07299006","phase":"NA","title":"Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children.","status":"NOT_YET_RECRUITING","sponsor":"Fondation Lenval","startDate":"2026-01-15","conditions":"Pain Management","enrollment":120},{"nctId":"NCT04199143","phase":"NA","title":"Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote)","status":"COMPLETED","sponsor":"University Hospital, Tours","startDate":"2020-02-20","conditions":"Treatment Resistant Depression, Nitrous Oxyde","enrollment":30},{"nctId":"NCT05007028","phase":"NA","title":"Nitrous Oxide for Late-Life Depression - 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Hôpitaux de Paris","startDate":"2009-02","conditions":"Colonoscopy Procedure","enrollment":220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"equimolar oxygen-nitrous oxide mixture","genericName":"equimolar oxygen-nitrous oxide mixture","companyName":"Centre Hospitalier Universitaire de Nīmes","companyId":"centre-hospitalier-universitaire-de-n-mes","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitrous oxide is a small molecule used in medical settings, including for pain relief in pediatric patients undergoing procedures such as lumbar puncture. It has been studied in various clinical trials for conditions such as leukemia, non-Hodgkin lymphoma, cardiac diseases, wounds, and dementia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}