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Epinephrine concentration of 1:500000
Epinephrine concentration of 1:500000 is a Catecholamine; alpha and beta-adrenergic agonist Small molecule drug developed by Al-Azhar University. It is currently in Phase 3 development for Adjunct to local anesthetics to prolong duration and reduce systemic toxicity, Emergency treatment of anaphylaxis, Acute hypotension and shock.
Epinephrine is a catecholamine that binds to alpha and beta adrenergic receptors, causing vasoconstriction, increased heart rate, and bronchodilation.
Epinephrine is a catecholamine that binds to alpha and beta adrenergic receptors, causing vasoconstriction, increased heart rate, and bronchodilation. Used for Adjunct to local anesthetics to prolong duration and reduce systemic toxicity, Emergency treatment of anaphylaxis, Acute hypotension and shock.
At a glance
| Generic name | Epinephrine concentration of 1:500000 |
|---|---|
| Sponsor | Al-Azhar University |
| Drug class | Catecholamine; alpha and beta-adrenergic agonist |
| Target | Alpha-1 adrenergic receptor; Alpha-2 adrenergic receptor; Beta-1 adrenergic receptor; Beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia; Cardiovascular; Respiratory |
| Phase | Phase 3 |
Mechanism of action
Epinephrine acts as both an alpha-1 and beta-adrenergic agonist. At the concentration of 1:500,000 (0.002 mg/mL), it is typically used as an adjunct to local anesthetics to prolong anesthetic effect and reduce systemic absorption through vasoconstriction. The drug increases cardiac output, elevates blood pressure, and relaxes bronchial smooth muscle.
Approved indications
- Adjunct to local anesthetics to prolong duration and reduce systemic toxicity
- Emergency treatment of anaphylaxis
- Acute hypotension and shock
Common side effects
- Tachycardia
- Hypertension
- Tremor
- Anxiety
- Headache
- Palpitations
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
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Related
- Drug class: All Catecholamine; alpha and beta-adrenergic agonist drugs
- Target: All drugs targeting Alpha-1 adrenergic receptor; Alpha-2 adrenergic receptor; Beta-1 adrenergic receptor; Beta-2 adrenergic receptor
- Manufacturer: Al-Azhar University — full pipeline
- Therapeutic area: All drugs in Anesthesia; Cardiovascular; Respiratory
- Indication: Drugs for Adjunct to local anesthetics to prolong duration and reduce systemic toxicity
- Indication: Drugs for Emergency treatment of anaphylaxis
- Indication: Drugs for Acute hypotension and shock
- Compare: Epinephrine concentration of 1:500000 vs similar drugs
- Pricing: Epinephrine concentration of 1:500000 cost, discount & access