{"id":"epinephrine-concentration-of-1-500000","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Palpitations"}]},"_chembl":{"chemblId":"CHEMBL1256958","moleculeType":"Small molecule","molecularWeight":"333.29"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Epinephrine acts as both an alpha-1 and beta-adrenergic agonist. At the concentration of 1:500,000 (0.002 mg/mL), it is typically used as an adjunct to local anesthetics to prolong anesthetic effect and reduce systemic absorption through vasoconstriction. The drug increases cardiac output, elevates blood pressure, and relaxes bronchial smooth muscle.","oneSentence":"Epinephrine is a catecholamine that binds to alpha and beta adrenergic receptors, causing vasoconstriction, increased heart rate, and bronchodilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:46:17.673Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Adjunct to local anesthetics to prolong duration and reduce systemic toxicity"},{"name":"Emergency treatment of anaphylaxis"},{"name":"Acute hypotension and shock"}]},"trialDetails":[{"nctId":"NCT05822765","phase":"PHASE3","title":"Effect of Adrenaline Concentration on Intraoperative Hemodynamics of Liposuction Patients","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2023-05-01","conditions":"Intraoperative Hemodynamics, Liposuction","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Epinephrine concentration of 1:500000","genericName":"Epinephrine concentration of 1:500000","companyName":"Al-Azhar University","companyId":"al-azhar-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epinephrine is a catecholamine that binds to alpha and beta adrenergic receptors, causing vasoconstriction, increased heart rate, and bronchodilation. Used for Adjunct to local anesthetics to prolong duration and reduce systemic toxicity, Emergency treatment of anaphylaxis, Acute hypotension and shock.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}