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Epiduo® Forte Gel
Epiduo Forte combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria.
Epiduo Forte combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria. Used for Acne vulgaris.
At a glance
| Generic name | Epiduo® Forte Gel |
|---|---|
| Also known as | Epiduo® Forte, Adapalene, benzoyl peroxide |
| Sponsor | Bausch Health Americas, Inc. |
| Drug class | Retinoid + antimicrobial combination |
| Target | Retinoic acid receptors (adapalene); bacterial cell membrane disruption (benzoyl peroxide) |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize follicular keratinization and reduce comedone formation. Benzoyl peroxide acts as an antimicrobial agent that kills Cutibacterium acnes (formerly Propionibacterium acnes) and has mild keratolytic properties. Together, they address multiple pathogenic factors in acne: abnormal keratinization, bacterial proliferation, and inflammation.
Approved indications
- Acne vulgaris
Common side effects
- Erythema
- Scaling/peeling
- Dryness
- Irritation
- Photosensitivity
Key clinical trials
- Experience With Topical Acne Treatment (EARLY_PHASE1)
- Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel (PHASE2)
- Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris (PHASE3)
- Study Comparing Adapalene/BP Gel to EPIDUO® FORTE and Both to a Placebo Control in Treatment of Acne Vulgaris (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |