{"id":"epiduo-forte-gel","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Erythema"},{"rate":"15-25","effect":"Scaling/peeling"},{"rate":"10-20","effect":"Dryness"},{"rate":"10-15","effect":"Irritation"},{"rate":"5-10","effect":"Photosensitivity"}]},"_chembl":{"chemblId":"CHEMBL3730724","moleculeType":"Small molecule","molecularWeight":"242.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Adapalene is a third-generation retinoid that binds to retinoic acid receptors to normalize follicular keratinization and reduce comedone formation. Benzoyl peroxide acts as an antimicrobial agent that kills Cutibacterium acnes (formerly Propionibacterium acnes) and has mild keratolytic properties. Together, they address multiple pathogenic factors in acne: abnormal keratinization, bacterial proliferation, and inflammation.","oneSentence":"Epiduo Forte combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:11:04.829Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT05582434","phase":"EARLY_PHASE1","title":"Experience With Topical Acne Treatment","status":"ACTIVE_NOT_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2024-02-15","conditions":"Acne","enrollment":72},{"nctId":"NCT04892706","phase":"PHASE2","title":"Study to Compare the Safety and Efficacy of IDP-126 Gel to Epiduo® Forte Gel and Vehicle Gel","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2021-06-11","conditions":"Acne Vulgaris","enrollment":686},{"nctId":"NCT02651220","phase":"PHASE3","title":"Clinical End Point Study of Generic Adapalene and Benzoyl Peroxide Gel Versus Epiduo® Forte Gel in Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2015-11","conditions":"Acne","enrollment":1001},{"nctId":"NCT02709902","phase":"PHASE1","title":"Study Comparing Adapalene/BP Gel to EPIDUO® FORTE and Both to a Placebo Control in Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Sun Pharmaceutical Industries, Inc.","startDate":"2015-09","conditions":"Acne Vulgaris","enrollment":460}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Epiduo® Forte","Adapalene, benzoyl peroxide"],"phase":"phase_3","status":"active","brandName":"Epiduo® Forte Gel","genericName":"Epiduo® Forte Gel","companyName":"Bausch Health Americas, Inc.","companyId":"bausch-health-americas-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Epiduo Forte combines adapalene (a retinoid) and benzoyl peroxide to reduce acne by normalizing skin cell turnover and killing acne-causing bacteria. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}