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Ephedrine-S
Ephedrine-S is a sympathomimetic amine that stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial airway dilation.
Ephedrine-S is a sympathomimetic amine that stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial airway dilation. Used for Hypotension and shock, Bronchospasm and asthma, Nasal congestion.
At a glance
| Generic name | Ephedrine-S |
|---|---|
| Also known as | vasopressor |
| Sponsor | Dalian Municipal Central Hospital |
| Drug class | Sympathomimetic amine |
| Target | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular, Respiratory |
| Phase | FDA-approved |
Mechanism of action
Ephedrine-S (the S-enantiomer of ephedrine) acts as a direct and indirect sympathomimetic agent, binding to adrenergic receptors and promoting norepinephrine release from nerve terminals. This results in increased cardiac output, peripheral vasoconstriction, and bronchodilation, making it useful for treating hypotension and bronchospasm. The S-enantiomer is the more pharmacologically active form compared to the R-enantiomer.
Approved indications
- Hypotension and shock
- Bronchospasm and asthma
- Nasal congestion
Common side effects
- Tachycardia
- Hypertension
- Tremor
- Anxiety
- Insomnia
- Headache
Key clinical trials
- Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial (NA)
- Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery (NA)
- A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia (PHASE4)
- Awake Nasal Fiber-optic Intubation of Severely Obese Patients in Lateral Position (NA)
- Clinical Trial Of The Effectiveness Of The Product Cloratadd D (Loratadine + Pseudoephedrine Sulfate) Produced By The Laboratory EMS S/A, Compared To The Drug Claritin D Produced By Schering-Plough S/A, In Patients With Allergic Rhinitis (PHASE3)
- Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery (EARLY_PHASE1)
- Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia (PHASE4)
- 4"S" - Seasonal Symptoms Suppression Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |