{"id":"ephedrine-s","safety":{"commonSideEffects":[{"rate":null,"effect":"Tachycardia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Tremor"},{"rate":null,"effect":"Anxiety"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ephedrine-S (the S-enantiomer of ephedrine) acts as a direct and indirect sympathomimetic agent, binding to adrenergic receptors and promoting norepinephrine release from nerve terminals. This results in increased cardiac output, peripheral vasoconstriction, and bronchodilation, making it useful for treating hypotension and bronchospasm. The S-enantiomer is the more pharmacologically active form compared to the R-enantiomer.","oneSentence":"Ephedrine-S is a sympathomimetic amine that stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial airway dilation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:45:34.725Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypotension and shock"},{"name":"Bronchospasm and asthma"},{"name":"Nasal congestion"}]},"trialDetails":[{"nctId":"NCT06836791","phase":"NA","title":"Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial","status":"COMPLETED","sponsor":"Youssef Zaki","startDate":"2023-03-01","conditions":"Anterior Epistaxis","enrollment":170},{"nctId":"NCT05662371","phase":"NA","title":"Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery","status":"RECRUITING","sponsor":"University of Southern Denmark","startDate":"2023-08-01","conditions":"Opioid Use, Unspecified, Pain, Postoperative","enrollment":60},{"nctId":"NCT06334549","phase":"PHASE4","title":"A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia","status":"RECRUITING","sponsor":"Dalian Municipal Central Hospital","startDate":"2024-03-05","conditions":"Hypotension Drug-Induced","enrollment":180},{"nctId":"NCT04779528","phase":"NA","title":"Awake Nasal Fiber-optic Intubation of Severely Obese Patients in Lateral Position","status":"COMPLETED","sponsor":"University of Jordan","startDate":"2021-03-01","conditions":"Anesthesia, Intubation;Difficult, Intubation; Difficult or Failed","enrollment":60},{"nctId":"NCT01055756","phase":"PHASE3","title":"Clinical Trial Of The Effectiveness Of The Product Cloratadd D (Loratadine + Pseudoephedrine Sulfate) Produced By The Laboratory EMS S/A, Compared To The Drug Claritin D Produced By Schering-Plough S/A, In Patients With Allergic Rhinitis","status":"WITHDRAWN","sponsor":"Azidus Brasil","startDate":"2010-01","conditions":"Allergic Rhinitis","enrollment":""},{"nctId":"NCT05294926","phase":"EARLY_PHASE1","title":"Comparison Of Deep Versus Moderate Neuromuscular Blockade on Intra-Operative Blood Loss During Spinal Surgery","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-04-01","conditions":"Spine Fracture","enrollment":88},{"nctId":"NCT03421860","phase":"PHASE4","title":"Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia","status":"COMPLETED","sponsor":"University Tunis El Manar","startDate":"2017-02-23","conditions":"Cardiac Output, Low","enrollment":120},{"nctId":"NCT02557269","phase":"PHASE4","title":"4\"S\" - Seasonal Symptoms Suppression Study","status":"UNKNOWN","sponsor":"Association Asthma, Bulgaria","startDate":"2015-05","conditions":"Seasonal Allergic Rhinitis","enrollment":60},{"nctId":"NCT01858090","phase":"PHASE3","title":"Intrathecal Levobupivacaine With Opioids for Caesarean Section","status":"COMPLETED","sponsor":"Baskent University","startDate":"2009-01","conditions":"Elective Caesarean Section Surgeries","enrollment":93},{"nctId":"NCT01744548","phase":"NA","title":"A Pilot Trial Of Transdiagnostic Cognitive Behavioural Therapy (tCBT) For Depression And Anxiety In Older People","status":"UNKNOWN","sponsor":"King's College London","startDate":"2012-12","conditions":"Depression, Anxiety","enrollment":22},{"nctId":"NCT01186549","phase":"PHASE1, PHASE2","title":"The Effect of Combined Ephedrine and Lidocaine Pretreatment on Pain and Hemodynamic Changes Due to Propofol Injection","status":"COMPLETED","sponsor":"Qazvin University Of Medical Sciences","startDate":"2010-08","conditions":"Pain Due to Propofol Injection, Hemodynamic Changes Due to Propofol Injection","enrollment":165}],"_emaApprovals":[],"_faersSignals":[{"count":3,"reaction":"DRUG INTERACTION"},{"count":2,"reaction":"CEREBROVASCULAR ACCIDENT"},{"count":1,"reaction":"AGITATION"},{"count":1,"reaction":"AMNESIA"},{"count":1,"reaction":"BLOOD PRESSURE INCREASED"},{"count":1,"reaction":"CONDITION AGGRAVATED"},{"count":1,"reaction":"CONFUSIONAL STATE"},{"count":1,"reaction":"DEPRESSION"},{"count":1,"reaction":"DISORIENTATION"},{"count":1,"reaction":"DIZZINESS"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["vasopressor"],"phase":"marketed","status":"active","brandName":"Ephedrine-S","genericName":"Ephedrine-S","companyName":"Dalian Municipal Central Hospital","companyId":"dalian-municipal-central-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ephedrine-S is a sympathomimetic amine that stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial airway dilation. Used for Hypotension and shock, Bronchospasm and asthma, Nasal congestion.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}