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Ephedrine Hydrochloride 3 MG/ML
Ephedrine Hydrochloride 3 MG/ML is a marketed sympathomimetic amine developed by University Hospital, Ghent, indicated for hypotension management during anesthesia and bronchial asthma treatment. The drug functions as a dual α- and β-adrenergic receptor agonist while indirectly stimulating norepinephrine release from sympathetic neurons. With 37 clinical trials completed and no published literature, the product represents an established therapeutic option in anesthesia and respiratory care. As a marketed formulation, it has established clinical utility but limited recent commercial development or pipeline expansion. The drug's mechanism provides rapid hemodynamic support and bronchodilation through multiple adrenergic pathways, making it valuable in acute clinical settings.
At a glance
| Generic name | Ephedrine Hydrochloride 3 MG/ML |
|---|---|
| Sponsor | University Hospital, Ghent |
| Drug class | Sympathomimetic amine; adrenergic agonist |
| Target | α-adrenergic receptors (α1, α2) and β-adrenergic receptors (β1, β2); sympathetic nerve terminals |
| Modality | Small molecule |
| Therapeutic area | Neuroscience |
| Phase | FDA-approved |
Approved indications
- Treatment of hypotension associated with anesthesia
- Treatment of bronchial asthma, transient or intermittent in nature, when oral therapy is not appropriate
Common side effects
Drug interactions
- oxytocin and oxytocic drugs
- clonidine
- propofol
- monoamine oxidase inhibitors (MAOIs)
- atropine
- α-adrenergic antagonists
- β-adrenergic receptor antagonists
- reserpine
- quinidine
- mephentermine
- guanethidine
- rocuronium
Key clinical trials
- Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine (PHASE4)
- Evaluation of the Early Use of Norepinephrine in Major Abdominal Surgery on Postoperative Organ Dysfunction (PHASE3)
- Minimal Flow Anesthesia and Infection Risk (NA)
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery (PHASE1)
- Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
- Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC (PHASE1, PHASE2)
- Ultrasonography for Fluid Assessment in Parturients With Preeclampsia Undergoing Cesarean Section
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ephedrine Hydrochloride 3 MG/ML CI brief — competitive landscape report
- Ephedrine Hydrochloride 3 MG/ML updates RSS · CI watch RSS
- University Hospital, Ghent portfolio CI