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Ephedrine, bolus
Ephedrine, bolus is a Sympathomimetic amine; adrenergic agonist Small molecule drug developed by University of Parma. It is currently FDA-approved for Hypotension and shock (acute hemodynamic support), Bronchospasm and asthma exacerbation, Nasal congestion.
Ephedrine is a sympathomimetic amine that stimulates alpha and beta adrenergic receptors to increase heart rate, blood pressure, and bronchial airway dilation.
Ephedrine is a small molecule adrenergic receptor agonist used in medical settings. It has been studied for various conditions, including post spinal hypotension, anesthesia, and acute kidney failure, as an intervention in clinical trials.
At a glance
| Generic name | Ephedrine, bolus |
|---|---|
| Sponsor | University of Parma |
| Drug class | Sympathomimetic amine; adrenergic agonist |
| Target | Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Respiratory |
| Phase | FDA-approved |
Mechanism of action
Ephedrine acts as a direct and indirect adrenergic agonist, binding to alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors. It increases norepinephrine release from nerve terminals and directly activates adrenergic receptors, resulting in increased cardiac output, peripheral vasoconstriction, and bronchodilation. The bolus formulation delivers rapid onset of action for acute hemodynamic support.
Approved indications
- Hypotension and shock (acute hemodynamic support)
- Bronchospasm and asthma exacerbation
- Nasal congestion
Common side effects
- Tachycardia
- Hypertension
- Tremor
- Anxiety and nervousness
- Insomnia
- Headache
- Palpitations
Key clinical trials
- Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section (NA)
- Hemodynamics During Cesarean Delivery Under Spinal Anesthesia With Norepinephrine Versus Ephedrine (PHASE4)
- Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery (PHASE3)
- The Noninvasive Blood Pressure Measurement Effect on the Hypotension (NA)
- Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia (PHASE4)
- Intravenous Administration of Magnesium Sulfate in Laparoscopic Hysterectomy Cases (NA)
- Management of Post-Induction Hypotension in Emergency Abdominal Surgery (PHASE4)
- Carotid Artery Corrected Flow Time and Inferior Vena Cava Collapsibility Index for Prediction of Hypotension After Induction of General Anesthesia in Geriatric Patients Undergoing Elective Surgery
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ephedrine, bolus CI brief — competitive landscape report
- Ephedrine, bolus updates RSS · CI watch RSS
- University of Parma portfolio CI
Frequently asked questions about Ephedrine, bolus
What is Ephedrine, bolus?
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Related
- Drug class: All Sympathomimetic amine; adrenergic agonist drugs
- Target: All drugs targeting Alpha-1, alpha-2, beta-1, and beta-2 adrenergic receptors
- Manufacturer: University of Parma — full pipeline
- Therapeutic area: All drugs in Cardiovascular; Respiratory
- Indication: Drugs for Hypotension and shock (acute hemodynamic support)
- Indication: Drugs for Bronchospasm and asthma exacerbation
- Indication: Drugs for Nasal congestion
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing