Last reviewed 2026-04-23 · How we verify

Eperisone hydrochloride

Eperisone hydrochloride is a muscle relaxant that reduces muscle tension by inhibiting monoamine oxidase and enhancing noradrenergic and serotonergic neurotransmission in the central nervous system.

Eperisone hydrochloride is a muscle relaxant that reduces muscle tension by inhibiting monoamine oxidase and enhancing noradrenergic and serotonergic neurotransmission in the central nervous system. Used for Muscle tension and spasticity associated with musculoskeletal disorders, Cervical spondylosis with muscle stiffness, Lower back pain with muscle tension.

At a glance

Mechanism of action

Eperisone acts as a centrally-acting muscle relaxant with properties that include monoamine oxidase inhibition and modulation of neurotransmitter levels. It reduces muscle stiffness and spasticity through effects on the spinal cord and brainstem, improving motor function without significant sedation. The drug is used primarily for musculoskeletal conditions characterized by muscle tension and spasticity.

Approved indications

• Muscle tension and spasticity associated with musculoskeletal disorders
• Cervical spondylosis with muscle stiffness
• Lower back pain with muscle tension

Common side effects

• Dizziness
• Headache
• Nausea
• Insomnia
• Tremor

Key clinical trials

• Study to Compare Pharmacokinetic Characteristics of Eperisone and Aceclofenac With NVP-1203 (PHASE1)
• Phase 3 Study to Evaluate the Efficacy and Safety of DW-1030 and Eperisone HCl in Acute Back Pain Patients (PHASE3)
• Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Eperisone HCl SR Tablet 75mg (PHASE1)
• A Clinical Study in Healthy Male Volunteers to Compare the Bioequivalence of Fixed Dose Combination of Eperisone Hydrochloride 50mg Plus Diclofenac Sodium 50mg as Capsule With Eperisone Hydrochloride 50mg and Diclofenac Sodium 50mg Tablets Under Fasting Conditions (Study 013-10) (NA)
• Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial (PHASE3)
• Study to Evaluate a Pharmacokinetic Drug Interaction Between Eperisone Hydrochloride and Aceclofenac in Healthy Male Subjects
• Partial Replicated Crossover Clinical Study to Compare Pharmacokinectic Characteristics of Eperisone Hydrochloride and Aceclofenac With HCP1104 Treatment to Those of Co-administration of Eperisone Hydrochloride 50mg Tablet and Aceclofenac 100mg Tablet in Healthy Adult Male Volunteers (PHASE1)
• Clinical Trial to Compare the Pharmacokinetics and Safety of Eperisone HCl SR Tablet 75mg and Myonal Tablet 50mg

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.