{"id":"eperisone-hydrochloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Insomnia"},{"rate":null,"effect":"Tremor"}]},"_chembl":{"chemblId":"CHEMBL1902981","moleculeType":"Small molecule","molecularWeight":"259.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Eperisone acts as a centrally-acting muscle relaxant with properties that include monoamine oxidase inhibition and modulation of neurotransmitter levels. It reduces muscle stiffness and spasticity through effects on the spinal cord and brainstem, improving motor function without significant sedation. The drug is used primarily for musculoskeletal conditions characterized by muscle tension and spasticity.","oneSentence":"Eperisone hydrochloride is a muscle relaxant that reduces muscle tension by inhibiting monoamine oxidase and enhancing noradrenergic and serotonergic neurotransmission in the central nervous system.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:46:17.319Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Muscle tension and spasticity associated with musculoskeletal disorders"},{"name":"Cervical spondylosis with muscle stiffness"},{"name":"Lower back pain with muscle tension"}]},"trialDetails":[{"nctId":"NCT02289274","phase":"PHASE1","title":"Study to Compare Pharmacokinetic Characteristics of Eperisone and Aceclofenac With NVP-1203","status":"WITHDRAWN","sponsor":"NVP Healthcare","startDate":"2019-11","conditions":"Healthy","enrollment":""},{"nctId":"NCT02040415","phase":"PHASE3","title":"Phase 3 Study to Evaluate the Efficacy and Safety of DW-1030 and Eperisone HCl in Acute Back Pain Patients","status":"COMPLETED","sponsor":"Daewon Pharmaceutical Co., Ltd.","startDate":"2014-03","conditions":"Acute Back Pain","enrollment":242},{"nctId":"NCT01885520","phase":"PHASE1","title":"Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Eperisone HCl SR Tablet 75mg","status":"COMPLETED","sponsor":"NVP Healthcare","startDate":"2013-07","conditions":"Low Back Pain","enrollment":28},{"nctId":"NCT01306318","phase":"NA","title":"A Clinical Study in Healthy Male Volunteers to Compare the Bioequivalence of Fixed Dose Combination of Eperisone Hydrochloride 50mg Plus Diclofenac Sodium 50mg as Capsule With Eperisone Hydrochloride 50mg and Diclofenac Sodium 50mg Tablets Under Fasting Conditions (Study 013-10)","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Healthy Volunteers","enrollment":24},{"nctId":"NCT00327730","phase":"PHASE3","title":"Evaluation of Eperisone HCl in the Treatment of Acute Musculoskeletal Spasm Associated With Low Back Pain - A Double Blind, Randomised, Placebo Controlled Clinical Trial","status":"COMPLETED","sponsor":"Eisai Inc.","startDate":"2006-04","conditions":"Muscle Spasm; Back Pain","enrollment":240},{"nctId":"NCT01638286","phase":"","title":"Study to Evaluate a Pharmacokinetic Drug Interaction Between Eperisone Hydrochloride and Aceclofenac in Healthy Male Subjects","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2012-08","conditions":"Acute Low Back Pain","enrollment":24},{"nctId":"NCT01869985","phase":"PHASE1","title":"Partial Replicated Crossover Clinical Study to Compare Pharmacokinectic Characteristics of Eperisone Hydrochloride and Aceclofenac With HCP1104 Treatment to Those of Co-administration of Eperisone Hydrochloride 50mg Tablet and Aceclofenac 100mg Tablet in Healthy Adult Male Volunteers","status":"COMPLETED","sponsor":"Hanmi Pharmaceutical Company Limited","startDate":"2013-08","conditions":"Healthy","enrollment":30},{"nctId":"NCT01775566","phase":"","title":"Clinical Trial to Compare the Pharmacokinetics and Safety of Eperisone HCl SR Tablet 75mg and Myonal Tablet 50mg","status":"COMPLETED","sponsor":"NVP Healthcare","startDate":"2013-03","conditions":"Low Back Pain","enrollment":27},{"nctId":"NCT01300312","phase":"PHASE3","title":"A Clinical Trial to Study the Effects of a Fixed Dose Combination of Diclofenac and Eperisone Hydrochloride With Plain Eperisone Hydrochloride in Patients With Low Back Pain","status":"COMPLETED","sponsor":"Eisai Co., Ltd.","startDate":"2011-02","conditions":"Acute Musculoskeletal Spasm Due to Low Back Pain","enrollment":239}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":48,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Eperisone hydrochloride","genericName":"Eperisone hydrochloride","companyName":"Eisai Co., Ltd.","companyId":"eisai-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Eperisone hydrochloride is a muscle relaxant that reduces muscle tension by inhibiting monoamine oxidase and enhancing noradrenergic and serotonergic neurotransmission in the central nervous system. Used for Muscle tension and spasticity associated with musculoskeletal disorders, Cervical spondylosis with muscle stiffness, Lower back pain with muscle tension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}