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Enamel Matrix Proteins
Enamel Matrix Proteins is a Regenerative biologic / Periodontal regenerative material Biologic drug developed by University of Campinas, Brazil. It is currently FDA-approved for Periodontal bone defects and intrabony pockets, Periodontal regeneration following scaling and root planing.
Enamel matrix proteins promote periodontal tissue regeneration by stimulating the migration, proliferation, and differentiation of periodontal ligament cells and osteoblasts.
Enamel matrix proteins promote periodontal tissue regeneration by stimulating the migration, proliferation, and differentiation of periodontal ligament cells and osteoblasts. Used for Periodontal bone defects and intrabony pockets, Periodontal regeneration following scaling and root planing.
At a glance
| Generic name | Enamel Matrix Proteins |
|---|---|
| Sponsor | University of Campinas, Brazil |
| Drug class | Regenerative biologic / Periodontal regenerative material |
| Modality | Biologic |
| Therapeutic area | Dentistry / Periodontics |
| Phase | FDA-approved |
Mechanism of action
Enamel matrix proteins are derived from porcine tooth buds and contain amelogenins and other bioactive proteins that mimic the natural extracellular matrix signaling environment during tooth development. When applied to periodontal defects, these proteins facilitate the recruitment and activation of progenitor cells, promoting new bone formation, cementum deposition, and periodontal ligament regeneration. This biological approach restores the functional attachment apparatus lost due to periodontal disease.
Approved indications
- Periodontal bone defects and intrabony pockets
- Periodontal regeneration following scaling and root planing
Common side effects
- Transient inflammation at application site
- Allergic reaction (rare, porcine-derived)
Key clinical trials
- Biologicals in Management of Intra-Bony Defects (NA)
- Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative (PHASE4)
- Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth. (NA)
- Comparison Between Emdogain and Amniotic Membrane as a Scaffold in Endodontic Regeneration of Immature Anterior Teeth (NA)
- Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®) (NA)
- Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth (PHASE4)
- Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions (NA)
- Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Enamel Matrix Proteins CI brief — competitive landscape report
- Enamel Matrix Proteins updates RSS · CI watch RSS
- University of Campinas, Brazil portfolio CI
Frequently asked questions about Enamel Matrix Proteins
What is Enamel Matrix Proteins?
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Related
- Drug class: All Regenerative biologic / Periodontal regenerative material drugs
- Manufacturer: University of Campinas, Brazil — full pipeline
- Therapeutic area: All drugs in Dentistry / Periodontics
- Indication: Drugs for Periodontal bone defects and intrabony pockets
- Indication: Drugs for Periodontal regeneration following scaling and root planing
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing