{"id":"enamel-matrix-proteins","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient inflammation at application site"},{"rate":null,"effect":"Allergic reaction (rare, porcine-derived)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Enamel matrix proteins are derived from porcine tooth buds and contain amelogenins and other bioactive proteins that mimic the natural extracellular matrix signaling environment during tooth development. When applied to periodontal defects, these proteins facilitate the recruitment and activation of progenitor cells, promoting new bone formation, cementum deposition, and periodontal ligament regeneration. This biological approach restores the functional attachment apparatus lost due to periodontal disease.","oneSentence":"Enamel matrix proteins promote periodontal tissue regeneration by stimulating the migration, proliferation, and differentiation of periodontal ligament cells and osteoblasts.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:29:15.086Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Periodontal bone defects and intrabony pockets"},{"name":"Periodontal regeneration following scaling and root planing"}]},"trialDetails":[{"nctId":"NCT07292870","phase":"NA","title":"Biologicals in Management of Intra-Bony Defects","status":"RECRUITING","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2025-08-08","conditions":"Intra-bony Pockets, Periodontitis","enrollment":30},{"nctId":"NCT05565079","phase":"PHASE4","title":"Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative","status":"COMPLETED","sponsor":"University of Louisville","startDate":"2022-10-06","conditions":"Recession, Gingival","enrollment":24},{"nctId":"NCT07310732","phase":"NA","title":"Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth.","status":"COMPLETED","sponsor":"Rungta College of Dental Sciences and Research","startDate":"2022-03-01","conditions":"Periodontal Diseases, Periodontal Bone Loss","enrollment":45},{"nctId":"NCT07252167","phase":"NA","title":"Comparison Between Emdogain and Amniotic Membrane as a Scaffold in Endodontic Regeneration of Immature Anterior Teeth","status":"ACTIVE_NOT_RECRUITING","sponsor":"Al-Azhar University","startDate":"2025-03-01","conditions":"Non-vital Immature Anterior Teeth","enrollment":39},{"nctId":"NCT07230522","phase":"NA","title":"Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®)","status":"COMPLETED","sponsor":"Medical University of Sofia","startDate":"2024-03-12","conditions":"Periodontitis, Intrabony Periodontal Defect, Periodontal Bone Loss","enrollment":17},{"nctId":"NCT07119307","phase":"PHASE4","title":"Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Treating Isolated Bone Defects Between Teeth","status":"COMPLETED","sponsor":"Rungta College of Dental Sciences and Research","startDate":"2023-05-30","conditions":"Periodontal Diseases, Intrabony Periodontal Defect","enrollment":58},{"nctId":"NCT07146464","phase":"NA","title":"Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions","status":"RECRUITING","sponsor":"Ain Shams University","startDate":"2024-03-27","conditions":"Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects","enrollment":18},{"nctId":"NCT04704089","phase":"","title":"Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects","status":"RECRUITING","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2022-07-18","conditions":"Amelogenesis Imperfecta, Dental Fluoroses, Hypomineralization Molar Incisor","enrollment":80},{"nctId":"NCT06504329","phase":"NA","title":"Clinical Outcomes of Enamel Matrix Derivative and Connective Tissue Graft in Modified Coronally Advanced Tunnel (MCAT)","status":"COMPLETED","sponsor":"Necmettin Erbakan University","startDate":"2024-01-24","conditions":"Gingival Recession","enrollment":52},{"nctId":"NCT06725095","phase":"NA","title":"Effects of Enamel Matrix Derivative in the Treatment of Peri-implant Mucositis","status":"ENROLLING_BY_INVITATION","sponsor":"University of Catania","startDate":"2024-12-05","conditions":"Mucositis, Peri Implant Mucositis","enrollment":54},{"nctId":"NCT06618560","phase":"NA","title":"Effect of Enamel Matrix Derivative or Hyaluronic Acid on Non-Surgical Treatment of Peri-Implantitis","status":"NOT_YET_RECRUITING","sponsor":"Gazi University","startDate":"2024-11-01","conditions":"Peri-implantitis","enrollment":60},{"nctId":"NCT05442034","phase":"PHASE1, PHASE2","title":"Rh-PDGF vs EMD for Treatment of Intra-bony Defects","status":"RECRUITING","sponsor":"Nova Southeastern University","startDate":"2023-01-01","conditions":"Intrabony Periodontal Defect","enrollment":36},{"nctId":"NCT06041854","phase":"NA","title":"Allograft With Enamel Matrix Derivative Versus Allograft Alone in the Treatment of Intrabony Defects .","status":"COMPLETED","sponsor":"Mansoura University","startDate":"2022-11-22","conditions":"Intrabony Periodontal Defect","enrollment":20},{"nctId":"NCT06250088","phase":"PHASE4","title":"Emdogain Adjunctive to Autotransplantation","status":"RECRUITING","sponsor":"Universidad Complutense de Madrid","startDate":"2024-03-12","conditions":"Autotransplantation, Emdogain, Autologous Transplantation","enrollment":20},{"nctId":"NCT05456555","phase":"NA","title":"The Flapless Approach in Periodontal Regeneration","status":"COMPLETED","sponsor":"University of Turin, Italy","startDate":"2022-09-01","conditions":"Periodontitis, Adult, Intrabony Periodontal Defect","enrollment":46},{"nctId":"NCT02972788","phase":"EARLY_PHASE1","title":"Effect of Enamel Matrix Proteins on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients","status":"COMPLETED","sponsor":"University of Nebraska","startDate":"2017-02-01","conditions":"Periodontal Bone Loss","enrollment":50},{"nctId":"NCT04059445","phase":"PHASE4","title":"Mandibular Furcation II Regeneration","status":"TERMINATED","sponsor":"University of Oslo","startDate":"2019-10-15","conditions":"Furcation Defects, Periodontal Diseases","enrollment":5},{"nctId":"NCT04059458","phase":"PHASE4","title":"Mandibular Furcation III Regeneration (FURC-III-REGEN)","status":"TERMINATED","sponsor":"University of Oslo","startDate":"2019-10-15","conditions":"Furcation Defects, Periodontal Diseases","enrollment":5},{"nctId":"NCT05799859","phase":"NA","title":"Treatment of Local Gingival Recession With an Enamel Matrix Protein Coated Collagen Matrix","status":"COMPLETED","sponsor":"Medical University of Graz","startDate":"2017-01-09","conditions":"Gingival Recession","enrollment":15},{"nctId":"NCT05507047","phase":"PHASE4","title":"Emdogain Implementation With Transcrestal Sinus Lifting and Dental Implant Placement","status":"COMPLETED","sponsor":"T.C. Dumlupınar Üniversitesi","startDate":"2017-01","conditions":"Osseointegration Failure of Dental Implant, Bone Density Increased","enrollment":24},{"nctId":"NCT02907528","phase":"NA","title":"Furcation Therapy With Enamel Matrix Derivative","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2014-01","conditions":"Chronic Periodontitis","enrollment":39},{"nctId":"NCT04274244","phase":"PHASE4","title":"Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.","status":"UNKNOWN","sponsor":"University of Valencia","startDate":"2020-03-01","conditions":"Chronic Periodontitis, Periodontal Bone Loss","enrollment":60},{"nctId":"NCT02551770","phase":"NA","title":"Emdogain Minimally Invasive Surgical Technique","status":"COMPLETED","sponsor":"Institut Straumann AG","startDate":"2015-10","conditions":"Periodontitis","enrollment":51},{"nctId":"NCT03467802","phase":"","title":"Collagen Matrix With and Without Enamel Matrix Derivative","status":"UNKNOWN","sponsor":"Walter Reed National Military Medical Center","startDate":"2019-01-01","conditions":"Gingival Recession","enrollment":30},{"nctId":"NCT03320135","phase":"NA","title":"EMD for Treatment of Proximal Class-II Furcation Involvements","status":"COMPLETED","sponsor":"Universidade Estadual Paulista Júlio de Mesquita Filho","startDate":"2017-10-20","conditions":"Generalized Aggressive Periodontitis","enrollment":34},{"nctId":"NCT03025204","phase":"PHASE4","title":"Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2016-02","conditions":"Aggressive Periodontitis","enrollment":45},{"nctId":"NCT03197610","phase":"NA","title":"The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2015-01-01","conditions":"Gingival Recession, Periodontal Diseases","enrollment":19},{"nctId":"NCT02474498","phase":"PHASE4","title":"EMD and/or Bone Substitute for the Treatment of Class II Furcations","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2013-03","conditions":"Periodontal Disease","enrollment":41},{"nctId":"NCT01030666","phase":"PHASE4","title":"Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy","status":"TERMINATED","sponsor":"Peter Eickholz","startDate":"2007-04","conditions":"Periodontitis","enrollment":61},{"nctId":"NCT02456337","phase":"PHASE4","title":"Xenogenous Collagen Matrix Graft With or Without Enamel Matrix Proteins Derivative for Root Coverage","status":"COMPLETED","sponsor":"University of Campinas, Brazil","startDate":"2014-07","conditions":"Gingival Recession","enrollment":49},{"nctId":"NCT02500654","phase":"PHASE4","title":"Regenerative Surgical Treatment of Peri-implantitis","status":"COMPLETED","sponsor":"Catrine Isehed","startDate":"2008-12","conditions":"Failure of Dental Implant Due to Infection, Infection, Inflammation","enrollment":31},{"nctId":"NCT00906776","phase":"NA","title":"Emdogain and Straumann Bone Ceramic in Infrabony Defects","status":"TERMINATED","sponsor":"Institut Straumann AG","startDate":"2007-04","conditions":"Periodontitis","enrollment":19},{"nctId":"NCT02195765","phase":"NA","title":"Randomized Clinical Trial of Enamel Matrix Derivative: Radiographic Analysis","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2002-06","conditions":"Chronic Periodontitis","enrollment":48},{"nctId":"NCT02135471","phase":"PHASE2","title":"Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2009-06","conditions":"Gingival Recession","enrollment":19},{"nctId":"NCT02102360","phase":"PHASE4","title":"Conventional or Minimally Invasive Surgical Technique for the Treatment of Furcation Defects Using Enamel Matrix Derivative and Anorganic Bovine Bone - a Randomized Controlled Clinical Trial.","status":"COMPLETED","sponsor":"University of Sao Paulo","startDate":"2012-03","conditions":"Furcation Defects, Periodontal Disease","enrollment":15},{"nctId":"NCT00757159","phase":"PHASE4","title":"Study on Regenerative Treatment of Intra-bony Defects","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2008-08","conditions":"Periodontal Disease, Periodontal Attachment Loss","enrollment":56},{"nctId":"NCT00720707","phase":"PHASE4","title":"Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage","status":"COMPLETED","sponsor":"Tabriz University","startDate":"2006-04","conditions":"Gingival Recession","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":511,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Enamel Matrix Proteins","genericName":"Enamel Matrix Proteins","companyName":"University of Campinas, Brazil","companyId":"university-of-campinas-brazil","modality":"Biologic","firstApprovalDate":"","aiSummary":"Enamel matrix proteins promote periodontal tissue regeneration by stimulating the migration, proliferation, and differentiation of periodontal ligament cells and osteoblasts. Used for Periodontal bone defects and intrabony pockets, Periodontal regeneration following scaling and root planing.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}