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EDTA root conditioning
EDTA (ethylenediaminetetraacetic acid) chelates calcium and other divalent cations in root surfaces to remove the smear layer and condition dentin for improved adhesion in endodontic and restorative procedures.
EDTA (ethylenediaminetetraacetic acid) chelates calcium and other divalent cations in root surfaces to remove the smear layer and condition dentin for improved adhesion in endodontic and restorative procedures. Used for Root canal treatment and endodontic therapy — root surface conditioning prior to sealer and cement placement, Restorative dentistry — dentin conditioning to improve adhesion of bonding agents and composite resins.
At a glance
| Generic name | EDTA root conditioning |
|---|---|
| Also known as | open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin). |
| Sponsor | Ain Shams University |
| Drug class | Chelating agent |
| Target | Calcium ions and divalent cations in mineralized tooth structure |
| Modality | Small molecule |
| Therapeutic area | Dentistry / Endodontics |
| Phase | FDA-approved |
Mechanism of action
EDTA is a chelating agent that binds to calcium ions in the mineralized tooth structure, dissolving the inorganic component of the smear layer created during root canal instrumentation. This demineralization exposes collagen fibrils and increases surface porosity, enhancing the penetration and adhesion of sealers, cements, and restorative materials to the root surface. The conditioning effect is reversible and time-dependent, typically requiring 1–10 minutes of application.
Approved indications
- Root canal treatment and endodontic therapy — root surface conditioning prior to sealer and cement placement
- Restorative dentistry — dentin conditioning to improve adhesion of bonding agents and composite resins
Common side effects
- Tooth sensitivity
- Mild irritation to periapical tissues if extruded beyond apex
- Demineralization of root surface (reversible with time)
Key clinical trials
- Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative (NA)
- A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects (NA)
- i-PRF & Root Surface Biomodification (NA)
- Healing of Intrabony Defects Following Treatment With PRF or EMD (PHASE4)
- Effect of Emdogain® on Soft Tissue Wound Healing (NA)
- The Flapless Approach in Periodontal Regeneration (NA)
- Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion. (NA)
- Flap Thickness Upon Root Coverage With the Use of Acellular Dermal Matrix (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |