{"id":"edta-root-conditioning","safety":{"commonSideEffects":[{"rate":null,"effect":"Tooth sensitivity"},{"rate":null,"effect":"Mild irritation to periapical tissues if extruded beyond apex"},{"rate":null,"effect":"Demineralization of root surface (reversible with time)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"EDTA is a chelating agent that binds to calcium ions in the mineralized tooth structure, dissolving the inorganic component of the smear layer created during root canal instrumentation. This demineralization exposes collagen fibrils and increases surface porosity, enhancing the penetration and adhesion of sealers, cements, and restorative materials to the root surface. The conditioning effect is reversible and time-dependent, typically requiring 1–10 minutes of application.","oneSentence":"EDTA (ethylenediaminetetraacetic acid) chelates calcium and other divalent cations in root surfaces to remove the smear layer and condition dentin for improved adhesion in endodontic and restorative procedures.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:52.952Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Root canal treatment and endodontic therapy — root surface conditioning prior to sealer and cement placement"},{"name":"Restorative dentistry — dentin conditioning to improve adhesion of bonding agents and composite resins"}]},"trialDetails":[{"nctId":"NCT07339605","phase":"NA","title":"Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative","status":"RECRUITING","sponsor":"University of Valencia","startDate":"2024-10-26","conditions":"Guided Tissue Regeneration, Periodontal / Methods, Dental Enamel Proteins* / Therapeutic Use, Alveolar Bone Loss* / Therapy","enrollment":60},{"nctId":"NCT07233733","phase":"NA","title":"A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodontal Defects","status":"COMPLETED","sponsor":"Phạm Đình Thiên Khải","startDate":"2024-06-01","conditions":"Periodontal Diseases, Regeneration","enrollment":17},{"nctId":"NCT07207668","phase":"NA","title":"i-PRF & Root Surface Biomodification","status":"COMPLETED","sponsor":"Halil Ata BIÇAKÇIOGLU","startDate":"2023-02-01","conditions":"Chronic Periodontitis (Disorder), Periodontitis","enrollment":42},{"nctId":"NCT07183631","phase":"PHASE4","title":"Healing of Intrabony Defects Following Treatment With PRF or EMD","status":"COMPLETED","sponsor":"Semmelweis University","startDate":"2021-09-01","conditions":"Periodontal Bone Loss, Periodontal Disease, Platelet Rich Fibrin","enrollment":28},{"nctId":"NCT06179277","phase":"NA","title":"Effect of Emdogain® on Soft Tissue Wound Healing","status":"COMPLETED","sponsor":"Amir Azarpazhooh","startDate":"2019-04-08","conditions":"Periodontal Inflammation, Crown Lengthening","enrollment":22},{"nctId":"NCT05456555","phase":"NA","title":"The Flapless Approach in Periodontal Regeneration","status":"COMPLETED","sponsor":"University of Turin, Italy","startDate":"2022-09-01","conditions":"Periodontitis, Adult, Intrabony Periodontal Defect","enrollment":46},{"nctId":"NCT05778227","phase":"NA","title":"Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.","status":"COMPLETED","sponsor":"Dow University of Health Sciences","startDate":"2021-11-16","conditions":"Root Canal Infection, Periapical Abscess, Irreversible Pulpitis","enrollment":100},{"nctId":"NCT04802473","phase":"NA","title":"Flap Thickness Upon Root Coverage With the Use of Acellular Dermal Matrix","status":"COMPLETED","sponsor":"Universitat Internacional de Catalunya","startDate":"2020-07-09","conditions":"Gingival Recession, Periodontal Attachment Loss, Periodontal Diseases","enrollment":20},{"nctId":"NCT04786327","phase":"PHASE2","title":"Minimally Invasive Flap With Platelet Rich Fibrin or Growth Factor Enhanced Matrix in Treatment of Intrabony Defect","status":"COMPLETED","sponsor":"Tanta University","startDate":"2018-01-01","conditions":"Periodontal Regeneration","enrollment":21},{"nctId":"NCT04274244","phase":"PHASE4","title":"Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration.","status":"UNKNOWN","sponsor":"University of Valencia","startDate":"2020-03-01","conditions":"Chronic Periodontitis, Periodontal Bone Loss","enrollment":60},{"nctId":"NCT04044417","phase":"PHASE4","title":"Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2016-08-25","conditions":"Periodontitis","enrollment":30},{"nctId":"NCT03419429","phase":"PHASE4","title":"Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2016-01","conditions":"Chronic Periodontitis","enrollment":40},{"nctId":"NCT01030666","phase":"PHASE4","title":"Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal Therapy","status":"TERMINATED","sponsor":"Peter Eickholz","startDate":"2007-04","conditions":"Periodontitis","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["open flap debridement followed by 24% EDTA root surface etching and application of curcumin-simvastatin paste (2% curcumin and 1.2% simvastatin)."],"phase":"marketed","status":"active","brandName":"EDTA root conditioning","genericName":"EDTA root conditioning","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"EDTA (ethylenediaminetetraacetic acid) chelates calcium and other divalent cations in root surfaces to remove the smear layer and condition dentin for improved adhesion in endodontic and restorative procedures. Used for Root canal treatment and endodontic therapy — root surface conditioning prior to sealer and cement placement, Restorative dentistry — dentin conditioning to improve adhesion of bonding agents and composite resins.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}